Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1243189..1243813 Replicon chromosome
Accession NC_021216
Organism Helicobacter pylori UM299

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K749_RS06155 Protein ID WP_000916178.1
Coordinates 1243547..1243813 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K749_RS06150 Protein ID WP_015644924.1
Coordinates 1243189..1243566 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K749_RS06120 1238334..1239446 + 1113 WP_015644921.1 hydrogenase formation protein HypD -
K749_RS06125 1239397..1240047 - 651 Protein_1166 hypothetical protein -
K749_RS06145 1240440..1242665 + 2226 WP_015644923.1 Hop family adhesin BabA -
K749_RS06150 1243189..1243566 + 378 WP_015644924.1 hypothetical protein Antitoxin
K749_RS06155 1243547..1243813 + 267 WP_000916178.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K749_RS06160 1243918..1244442 - 525 WP_001120212.1 acyl-CoA thioesterase -
K749_RS06165 1244583..1245431 + 849 WP_015644925.1 SDR family oxidoreductase -
K749_RS06170 1245424..1246404 + 981 WP_015644926.1 iron ABC transporter permease -
K749_RS06175 1246404..1247171 + 768 WP_000242365.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10273.15 Da        Isoelectric Point: 9.9840

>T29431 WP_000916178.1 NC_021216:1243547-1243813 [Helicobacter pylori UM299]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVRGDELILVR
LGSHSELF

Download         Length: 267 bp

>T29431 NC_021216:1243547-1243813 [Helicobacter pylori UM299]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTACTTGTGTATTTGGTGAGAGGTGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14775.81 Da        Isoelectric Point: 9.4267

>AT29431 WP_015644924.1 NC_021216:1243189-1243566 [Helicobacter pylori UM299]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKRMQNDRASFKEKMAKELEKRDQNFKDKIDALNKLLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp

>AT29431 NC_021216:1243189-1243566 [Helicobacter pylori UM299]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAGATCAAAAGGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACTGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References