Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2744925..2745454 Replicon chromosome
Accession NZ_LT992474
Organism Staphylococcus aureus isolate 19_LA_388

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE66_RS14145 Protein ID WP_000621175.1
Coordinates 2744925..2745287 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE66_RS14150 Protein ID WP_000948331.1
Coordinates 2745284..2745454 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE66_RS14120 2741903..2742673 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
DXE66_RS14125 2742648..2743127 - 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE66_RS14130 2743129..2743455 - 327 WP_001052491.1 anti-sigma factor antagonist -
DXE66_RS14135 2743574..2744575 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE66_RS14145 2744925..2745287 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE66_RS14150 2745284..2745454 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE66_RS14155 2745539..2746687 - 1149 WP_001281139.1 alanine racemase -
DXE66_RS14160 2746753..2747112 - 360 WP_000581197.1 holo-ACP synthase -
DXE66_RS14165 2747116..2747607 - 492 WP_001286980.1 PH domain-containing protein -
DXE66_RS14170 2747600..2749177 - 1578 WP_001294650.1 PH domain-containing protein -
DXE66_RS14175 2749170..2749649 - 480 WP_001287081.1 hypothetical protein -
DXE66_RS14180 2749858..2750418 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294291 WP_000621175.1 NZ_LT992474:c2745287-2744925 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294291 WP_000948331.1 NZ_LT992474:c2745454-2745284 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References