Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2541138..2541914 Replicon chromosome
Accession NZ_LT992474
Organism Staphylococcus aureus isolate 19_LA_388

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DXE66_RS12835 Protein ID WP_000031108.1
Coordinates 2541138..2541290 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DXE66_RS12840 Protein ID WP_001251224.1
Coordinates 2541315..2541914 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE66_RS12815 2537343..2538164 + 822 WP_000669380.1 RluA family pseudouridine synthase -
DXE66_RS12820 2538619..2540004 - 1386 WP_000116238.1 class II fumarate hydratase -
DXE66_RS12825 2540200..2540595 - 396 WP_000901018.1 hypothetical protein -
DXE66_RS12835 2541138..2541290 - 153 WP_000031108.1 hypothetical protein Toxin
DXE66_RS12840 2541315..2541914 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
DXE66_RS12845 2542073..2542543 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DXE66_RS12850 2542548..2543675 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
DXE66_RS12855 2543826..2544548 - 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
DXE66_RS12860 2544541..2545998 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T294286 WP_000031108.1 NZ_LT992474:c2541290-2541138 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT294286 WP_001251224.1 NZ_LT992474:c2541914-2541315 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References