Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2600963..2601492 Replicon chromosome
Accession NZ_LT992473
Organism Staphylococcus aureus isolate 14_5418

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE48_RS13115 Protein ID WP_000621175.1
Coordinates 2601130..2601492 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE48_RS13110 Protein ID WP_000948331.1
Coordinates 2600963..2601133 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE48_RS13080 2595999..2596559 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
DXE48_RS13085 2596768..2597247 + 480 WP_001287081.1 hypothetical protein -
DXE48_RS13090 2597240..2598817 + 1578 WP_001294650.1 PH domain-containing protein -
DXE48_RS13095 2598810..2599301 + 492 WP_001286980.1 PH domain-containing protein -
DXE48_RS13100 2599305..2599664 + 360 WP_000581197.1 holo-ACP synthase -
DXE48_RS13105 2599730..2600878 + 1149 WP_001281139.1 alanine racemase -
DXE48_RS13110 2600963..2601133 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE48_RS13115 2601130..2601492 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE48_RS13125 2601842..2602843 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE48_RS13130 2602962..2603288 + 327 WP_001052491.1 anti-sigma factor antagonist -
DXE48_RS13135 2603290..2603769 + 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE48_RS13140 2603744..2604514 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294275 WP_000621175.1 NZ_LT992473:2601130-2601492 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294275 WP_000948331.1 NZ_LT992473:2600963-2601133 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References