Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1340771..1341445 | Replicon | chromosome |
Accession | NC_021213 | ||
Organism | Streptococcus suis TL13 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | V6Z2K9 |
Locus tag | TL13_RS06535 | Protein ID | WP_015647112.1 |
Coordinates | 1341263..1341445 (-) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A116K2F0 |
Locus tag | TL13_RS06530 | Protein ID | WP_015647111.1 |
Coordinates | 1340771..1341223 (-) | Length | 151 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
TL13_RS06505 | 1336260..1337426 | - | 1167 | WP_015647106.1 | AI-2E family transporter | - |
TL13_RS06510 | 1337562..1338566 | + | 1005 | WP_015647107.1 | lactonase family protein | - |
TL13_RS06515 | 1338630..1338815 | + | 186 | WP_002935693.1 | hypothetical protein | - |
TL13_RS06520 | 1338843..1339490 | - | 648 | WP_015647108.1 | HAD family hydrolase | - |
TL13_RS06525 | 1340448..1340657 | - | 210 | WP_015647110.1 | hypothetical protein | - |
TL13_RS06530 | 1340771..1341223 | - | 453 | WP_015647111.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
TL13_RS06535 | 1341263..1341445 | - | 183 | WP_015647112.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
TL13_RS10395 | 1341931..1342095 | - | 165 | WP_079266802.1 | hypothetical protein | - |
TL13_RS06545 | 1342185..1342598 | - | 414 | WP_015647113.1 | hypothetical protein | - |
TL13_RS06550 | 1342616..1342927 | - | 312 | WP_024414029.1 | hypothetical protein | - |
TL13_RS06555 | 1342935..1343363 | - | 429 | WP_015647114.1 | hypothetical protein | - |
TL13_RS06560 | 1343543..1344142 | - | 600 | WP_015647115.1 | hypothetical protein | - |
TL13_RS10675 | 1344224..1344385 | - | 162 | WP_105105015.1 | DUF2292 domain-containing protein | - |
TL13_RS06565 | 1344743..1345588 | - | 846 | WP_015647117.1 | ATP-binding protein | - |
TL13_RS06570 | 1345604..1346398 | - | 795 | WP_024414030.1 | DnaD domain protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1338630..1351689 | 13059 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6630.84 Da Isoelectric Point: 10.8207
>T29427 WP_015647112.1 NC_021213:c1341445-1341263 [Streptococcus suis TL13]
MPMTQKEMVKLLTANGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL
MPMTQKEMVKLLTANGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL
Download Length: 183 bp
>T29427 NC_021213:c1341445-1341263 [Streptococcus suis TL13]
ATGCCTATGACACAAAAAGAAATGGTTAAACTTCTTACCGCCAACGGTTGGACAAAGACCAAAGGCGGTAAAGGGTCACA
CGTTAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA
ATGCCTATGACACAAAAAGAAATGGTTAAACTTCTTACCGCCAACGGTTGGACAAAGACCAAAGGCGGTAAAGGGTCACA
CGTTAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA
Antitoxin
Download Length: 151 a.a. Molecular weight: 16711.67 Da Isoelectric Point: 3.9495
>AT29427 WP_015647111.1 NC_021213:c1341223-1340771 [Streptococcus suis TL13]
MLVTYPALFYYDDTDGASAPYFVTFPDFEHSATQGEDMANAMAMASDWLGIHLADYIENGRDIPTPTPINTLSLADNNPF
HDDEDIELIYDPSKSFISMVMVDVAEYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA
MLVTYPALFYYDDTDGASAPYFVTFPDFEHSATQGEDMANAMAMASDWLGIHLADYIENGRDIPTPTPINTLSLADNNPF
HDDEDIELIYDPSKSFISMVMVDVAEYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA
Download Length: 453 bp
>AT29427 NC_021213:c1341223-1340771 [Streptococcus suis TL13]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTAGCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAAGGCGAAGATATGGCAAACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGAGATATTCCCACTCCTACCCCTATTAACACCTTATCTTTAGCAGATAATAACCCTTTC
CATGATGATGAGGATATAGAGCTTATCTATGACCCTAGTAAGTCTTTTATTTCTATGGTTATGGTTGATGTTGCCGAGTA
TTTAGGTAGCCAAGAACCTATAAAGAAAACTCTAACTATCCCACGTTGGGCGGATACTTTAGGGCGTGAGCTAGGATTGA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTAGCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAAGGCGAAGATATGGCAAACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGAGATATTCCCACTCCTACCCCTATTAACACCTTATCTTTAGCAGATAATAACCCTTTC
CATGATGATGAGGATATAGAGCTTATCTATGACCCTAGTAAGTCTTTTATTTCTATGGTTATGGTTGATGTTGCCGAGTA
TTTAGGTAGCCAAGAACCTATAAAGAAAACTCTAACTATCCCACGTTGGGCGGATACTTTAGGGCGTGAGCTAGGATTGA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V6Z2K9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A116K2F0 |