Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1340771..1341445 Replicon chromosome
Accession NC_021213
Organism Streptococcus suis TL13

Toxin (Protein)


Gene name hicA Uniprot ID V6Z2K9
Locus tag TL13_RS06535 Protein ID WP_015647112.1
Coordinates 1341263..1341445 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A116K2F0
Locus tag TL13_RS06530 Protein ID WP_015647111.1
Coordinates 1340771..1341223 (-) Length 151 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TL13_RS06505 1336260..1337426 - 1167 WP_015647106.1 AI-2E family transporter -
TL13_RS06510 1337562..1338566 + 1005 WP_015647107.1 lactonase family protein -
TL13_RS06515 1338630..1338815 + 186 WP_002935693.1 hypothetical protein -
TL13_RS06520 1338843..1339490 - 648 WP_015647108.1 HAD family hydrolase -
TL13_RS06525 1340448..1340657 - 210 WP_015647110.1 hypothetical protein -
TL13_RS06530 1340771..1341223 - 453 WP_015647111.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
TL13_RS06535 1341263..1341445 - 183 WP_015647112.1 type II toxin-antitoxin system HicA family toxin Toxin
TL13_RS10395 1341931..1342095 - 165 WP_079266802.1 hypothetical protein -
TL13_RS06545 1342185..1342598 - 414 WP_015647113.1 hypothetical protein -
TL13_RS06550 1342616..1342927 - 312 WP_024414029.1 hypothetical protein -
TL13_RS06555 1342935..1343363 - 429 WP_015647114.1 hypothetical protein -
TL13_RS06560 1343543..1344142 - 600 WP_015647115.1 hypothetical protein -
TL13_RS10675 1344224..1344385 - 162 WP_105105015.1 DUF2292 domain-containing protein -
TL13_RS06565 1344743..1345588 - 846 WP_015647117.1 ATP-binding protein -
TL13_RS06570 1345604..1346398 - 795 WP_024414030.1 DnaD domain protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1338630..1351689 13059


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6630.84 Da        Isoelectric Point: 10.8207

>T29427 WP_015647112.1 NC_021213:c1341445-1341263 [Streptococcus suis TL13]
MPMTQKEMVKLLTANGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T29427 NC_021213:c1341445-1341263 [Streptococcus suis TL13]
ATGCCTATGACACAAAAAGAAATGGTTAAACTTCTTACCGCCAACGGTTGGACAAAGACCAAAGGCGGTAAAGGGTCACA
CGTTAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16711.67 Da        Isoelectric Point: 3.9495

>AT29427 WP_015647111.1 NC_021213:c1341223-1340771 [Streptococcus suis TL13]
MLVTYPALFYYDDTDGASAPYFVTFPDFEHSATQGEDMANAMAMASDWLGIHLADYIENGRDIPTPTPINTLSLADNNPF
HDDEDIELIYDPSKSFISMVMVDVAEYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT29427 NC_021213:c1341223-1340771 [Streptococcus suis TL13]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTAGCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAAGGCGAAGATATGGCAAACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGAGATATTCCCACTCCTACCCCTATTAACACCTTATCTTTAGCAGATAATAACCCTTTC
CATGATGATGAGGATATAGAGCTTATCTATGACCCTAGTAAGTCTTTTATTTCTATGGTTATGGTTGATGTTGCCGAGTA
TTTAGGTAGCCAAGAACCTATAAAGAAAACTCTAACTATCCCACGTTGGGCGGATACTTTAGGGCGTGAGCTAGGATTGA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V6Z2K9


Antitoxin

Source ID Structure
AlphaFold DB A0A116K2F0

References