Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 958694..959180 Replicon chromosome
Accession NC_021213
Organism Streptococcus suis TL13

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8L0Q0
Locus tag TL13_RS04775 Protein ID WP_015646834.1
Coordinates 958923..959180 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A123SEG2
Locus tag TL13_RS04770 Protein ID WP_015646833.1
Coordinates 958694..958933 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TL13_RS04745 954024..955190 + 1167 WP_015646828.1 carbamoyl phosphate synthase large subunit -
TL13_RS04750 955329..955469 + 141 WP_015646829.1 hypothetical protein -
TL13_RS04755 955482..955871 + 390 WP_015646830.1 NisI/SpaI family lantibiotic immunity lipoprotein -
TL13_RS04760 955880..956632 + 753 WP_015646831.1 ABC transporter ATP-binding protein -
TL13_RS04765 956633..958603 + 1971 WP_015646832.1 ABC transporter permease -
TL13_RS04770 958694..958933 + 240 WP_015646833.1 hypothetical protein Antitoxin
TL13_RS04775 958923..959180 + 258 WP_015646834.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TL13_RS04780 959218..959886 + 669 WP_024381849.1 response regulator transcription factor -
TL13_RS04785 959883..960824 + 942 WP_015646835.1 sensor histidine kinase -
TL13_RS04790 960901..962409 + 1509 WP_015646836.1 phosphomannomutase/phosphoglucomutase -
TL13_RS04795 962479..963549 - 1071 WP_015646837.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9808.47 Da        Isoelectric Point: 10.7134

>T29426 WP_015646834.1 NC_021213:958923-959180 [Streptococcus suis TL13]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALIANRSGQWRYRIGNYRVIVSIEDDKVTVTSLKM
RNGSI

Download         Length: 258 bp

>T29426 NC_021213:958923-959180 [Streptococcus suis TL13]
TTGAGTTATAAGGTTATTTTGTCCGCTAAGGCTCAAAAGCAAATTCGAAAGATGGATAAAACTGCTGCAAGTTTGATTTT
GCGGTATCTTTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGATTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGATGACAAAGTGACAGTTACAAGTCTAAAAATG
AGAAATGGAAGTATATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8879.09 Da        Isoelectric Point: 3.7832

>AT29426 WP_015646833.1 NC_021213:958694-958933 [Streptococcus suis TL13]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT29426 NC_021213:958694-958933 [Streptococcus suis TL13]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGATAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCACTTGAAGATGAGTACGATGCGCGTGTGGCAGATATTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATAACACTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8L0Q0

Antitoxin

Source ID Structure
AlphaFold DB A0A123SEG2

References