Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 252262..252791 Replicon chromosome
Accession NZ_LT992472
Organism Staphylococcus aureus isolate 10_5235

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE26_RS01455 Protein ID WP_000621175.1
Coordinates 252262..252624 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE26_RS01460 Protein ID WP_000948331.1
Coordinates 252621..252791 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE26_RS01430 249240..250010 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
DXE26_RS01435 249985..250464 - 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE26_RS01440 250466..250792 - 327 WP_001052491.1 anti-sigma factor antagonist -
DXE26_RS01445 250911..251912 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE26_RS01455 252262..252624 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE26_RS01460 252621..252791 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE26_RS01465 252876..254024 - 1149 WP_001281139.1 alanine racemase -
DXE26_RS01470 254090..254449 - 360 WP_000581197.1 holo-ACP synthase -
DXE26_RS01475 254453..254944 - 492 WP_001286980.1 PH domain-containing protein -
DXE26_RS01480 254937..256514 - 1578 WP_001294650.1 PH domain-containing protein -
DXE26_RS01485 256507..256986 - 480 WP_001287081.1 hypothetical protein -
DXE26_RS01490 257195..257755 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294254 WP_000621175.1 NZ_LT992472:c252624-252262 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294254 WP_000948331.1 NZ_LT992472:c252791-252621 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References