294246

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2252263..2252792 Replicon chromosome
Accession NZ_LT992471
Organism Staphylococcus aureus isolate 17_LA_343

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE46_RS11720 Protein ID WP_000621175.1
Coordinates 2252263..2252625 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE46_RS11725 Protein ID WP_000948331.1
Coordinates 2252622..2252792 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE46_RS11695 2249241..2250011 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
DXE46_RS11700 2249986..2250465 - 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE46_RS11705 2250467..2250793 - 327 WP_001052491.1 anti-sigma factor antagonist -
DXE46_RS11710 2250912..2251913 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE46_RS11720 2252263..2252625 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE46_RS11725 2252622..2252792 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE46_RS11730 2252877..2254025 - 1149 WP_001281139.1 alanine racemase -
DXE46_RS11735 2254091..2254450 - 360 WP_000581197.1 holo-ACP synthase -
DXE46_RS11740 2254454..2254945 - 492 WP_001286980.1 PH domain-containing protein -
DXE46_RS11745 2254938..2256515 - 1578 WP_001294650.1 PH domain-containing protein -
DXE46_RS11750 2256508..2256987 - 480 WP_001287081.1 hypothetical protein -
DXE46_RS11755 2257196..2257756 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294246 WP_000621175.1 NZ_LT992471:c2252625-2252263 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294246 WP_000948331.1 NZ_LT992471:c2252792-2252622 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References