294214

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 711747..712535 Replicon chromosome
Accession NZ_LT992469
Organism Staphylococcus aureus isolate 15_LA_305

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag DXE36_RS03975 Protein ID WP_000525004.1
Coordinates 711747..712208 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag DXE36_RS03980 Protein ID WP_000333630.1
Coordinates 712221..712535 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE36_RS03950 706772..708799 + 2028 WP_014532489.1 hypothetical protein -
DXE36_RS03955 708842..710047 - 1206 WP_031871821.1 site-specific integrase -
DXE36_RS03960 710158..710772 + 615 WP_000191466.1 hypothetical protein -
DXE36_RS03965 710769..710915 - 147 WP_001794606.1 hypothetical protein -
DXE36_RS03970 711145..711729 - 585 WP_000825948.1 hypothetical protein -
DXE36_RS03975 711747..712208 - 462 WP_000525004.1 hypothetical protein Toxin
DXE36_RS03980 712221..712535 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
DXE36_RS03985 712687..712923 + 237 WP_001121027.1 helix-turn-helix domain-containing protein -
DXE36_RS03990 712937..713713 + 777 WP_001148544.1 Rha family transcriptional regulator -
DXE36_RS14990 713742..713891 + 150 WP_000771849.1 hypothetical protein -
DXE36_RS03995 713932..714144 - 213 WP_000362644.1 hypothetical protein -
DXE36_RS04000 714214..714411 + 198 WP_001148860.1 hypothetical protein -
DXE36_RS04005 714398..714778 - 381 WP_000773059.1 DUF2513 domain-containing protein -
DXE36_RS04010 714845..715090 + 246 WP_001025401.1 DUF2829 domain-containing protein -
DXE36_RS04015 715059..715424 - 366 WP_001128433.1 hypothetical protein -
DXE36_RS04020 715479..715694 + 216 WP_001097552.1 hypothetical protein -
DXE36_RS04025 715721..715984 + 264 WP_001596347.1 helix-turn-helix domain-containing protein -
DXE36_RS04030 715997..716158 + 162 WP_001285948.1 DUF1270 domain-containing protein -
DXE36_RS04035 716237..716560 + 324 WP_000174994.1 hypothetical protein -
DXE36_RS04040 716575..716937 + 363 WP_031863778.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 705850..756024 50174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T294214 WP_000525004.1 NZ_LT992469:c712208-711747 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT294214 WP_000333630.1 NZ_LT992469:c712535-712221 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References