294208

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 133769..134283 Replicon chromosome
Accession NZ_LT992469
Organism Staphylococcus aureus isolate 15_LA_305

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DXE36_RS00735 Protein ID WP_000581792.1
Coordinates 134074..134283 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DXE36_RS00730 Protein ID WP_000138932.1
Coordinates 133769..134062 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE36_RS00710 129532..130847 + 1316 Protein_125 ISL3 family transposase -
DXE36_RS00715 130844..131164 - 321 WP_001825748.1 hypothetical protein -
DXE36_RS00720 131444..132091 - 648 WP_001187614.1 HD domain-containing protein -
DXE36_RS00725 132119..133603 - 1485 WP_000571550.1 cardiolipin synthase -
DXE36_RS00730 133769..134062 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DXE36_RS00735 134074..134283 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DXE36_RS00740 134411..134548 + 138 WP_000828354.1 hypothetical protein -
DXE36_RS00745 134812..136014 - 1203 WP_001109939.1 rod shape-determining protein RodA -
DXE36_RS00750 136332..137402 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
DXE36_RS00755 137417..138772 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T294208 WP_000581792.1 NZ_LT992469:134074-134283 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT294208 WP_000138932.1 NZ_LT992469:133769-134062 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References