294196

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 631143..631672 Replicon chromosome
Accession NZ_LT992468
Organism Staphylococcus aureus isolate 12_LA_293

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE47_RS03730 Protein ID WP_000621175.1
Coordinates 631143..631505 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE47_RS03735 Protein ID WP_000948331.1
Coordinates 631502..631672 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE47_RS03705 628121..628891 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
DXE47_RS03710 628866..629345 - 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE47_RS03715 629347..629673 - 327 WP_001052491.1 anti-sigma factor antagonist -
DXE47_RS03720 629792..630793 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE47_RS03730 631143..631505 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE47_RS03735 631502..631672 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE47_RS03740 631757..632905 - 1149 WP_001281139.1 alanine racemase -
DXE47_RS03745 632971..633330 - 360 WP_000581197.1 holo-ACP synthase -
DXE47_RS03750 633334..633825 - 492 WP_001286980.1 PH domain-containing protein -
DXE47_RS03755 633818..635395 - 1578 WP_001294650.1 PH domain-containing protein -
DXE47_RS03760 635388..635867 - 480 WP_001287081.1 hypothetical protein -
DXE47_RS03765 636076..636636 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294196 WP_000621175.1 NZ_LT992468:c631505-631143 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294196 WP_000948331.1 NZ_LT992468:c631672-631502 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References