Detailed information of TA system TA029419

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-RelB
• Location: 4657826..4658327
• Replicon: chromosome
• Accession: NC_021184
• Organism: Desulfotomaculum gibsoniae DSM 7213

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: R4KM89
• Locus tag: DESGI_RS21735
• Protein ID: WP_006522357.1
• Coordinates: 4657826..4658080 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4KT76
• Locus tag: DESGI_RS21740
• Protein ID: WP_006522356.1
• Coordinates: 4658073..4658327 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DESGI_RS21725	4655935..4657062	-	1128	WP_006522359.1	efflux RND transporter periplasmic adaptor subunit	-
DESGI_RS21730	4657158..4657643	-	486	WP_006522358.1	MarR family transcriptional regulator	-
DESGI_RS21735	4657826..4658080	-	255	WP_006522357.1	Txe/YoeB family addiction module toxin	Toxin
DESGI_RS21740	4658073..4658327	-	255	WP_006522356.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DESGI_RS21745	4658499..4660211	-	1713	WP_006522355.1	copper amine oxidase	-
DESGI_RS21750	4660400..4661503	-	1104	WP_006522354.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10042.34 Da
• Isoelectric Point: 8.0293

>T29419 WP_006522357.1 NC_021184:c4658080-4657826 [Desulfallas gibsoniae DSM 7213]
MNKIFSDVAWQHYLYWQSEDKKILKKVNELLRDIDRNGNEGLGKPEPLKNELSGYWSRRITDVHRLIYSIDNDNIYIASC
RGHY

Nucleotide

• Length: 255 bp

>T29419 NC_021184:c4658080-4657826 [Desulfallas gibsoniae DSM 7213]
ATGAATAAAATCTTTTCGGATGTAGCATGGCAGCATTACTTGTATTGGCAATCAGAGGACAAAAAAATATTAAAGAAAGT
CAATGAGCTATTACGAGATATTGATAGAAATGGAAATGAAGGATTGGGCAAGCCGGAGCCACTGAAAAATGAATTATCCG
GATATTGGAGTCGCCGTATTACTGATGTTCATCGACTAATATATAGTATTGATAATGACAATATTTATATAGCTAGTTGC
AGAGGTCACTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9912.28 Da
• Isoelectric Point: 7.9383

>AT29419 WP_006522356.1 NC_021184:c4658327-4658073 [Desulfallas gibsoniae DSM 7213]
MIATSYSSVRQNFKKYCDKAVNDFETIIITRERGENVVMLSEAEYNNLLENLYVRSNPKYYNELLQSIEQLKKGKGKKRE
LLDE

Nucleotide

• Length: 255 bp

>AT29419 NC_021184:c4658327-4658073 [Desulfallas gibsoniae DSM 7213]
ATGATAGCAACAAGCTATTCGTCTGTAAGGCAAAATTTTAAAAAATATTGTGACAAGGCTGTAAACGATTTTGAAACAAT
TATTATTACTCGTGAACGTGGCGAGAATGTAGTTATGCTATCCGAAGCAGAGTATAATAACCTTTTAGAAAATCTCTATG
TGAGAAGTAATCCAAAATACTATAACGAACTTTTACAGTCTATAGAGCAATTAAAAAAAGGCAAGGGAAAGAAAAGAGAA
TTGCTTGATGAATAA

Structures

Toxin

• AlphaFold DB: R4KM89

Antitoxin

• AlphaFold DB: R4KT76