Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 4486710..4487244 Replicon chromosome
Accession NC_021184
Organism Desulfotomaculum gibsoniae DSM 7213

Toxin (Protein)


Gene name relE Uniprot ID R4KVJ1
Locus tag DESGI_RS20885 Protein ID WP_006521309.1
Coordinates 4486710..4486982 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4KQ28
Locus tag DESGI_RS20890 Protein ID WP_006521308.1
Coordinates 4486969..4487244 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DESGI_RS20850 4482602..4484512 + 1911 WP_006521315.1 primase -
DESGI_RS20855 4484713..4485057 + 345 WP_006521314.1 hypothetical protein -
DESGI_RS20860 4485047..4485271 + 225 WP_006521313.1 hypothetical protein -
DESGI_RS20865 4485261..4485693 + 433 Protein_4187 DUF1492 domain-containing protein -
DESGI_RS20870 4485801..4486007 + 207 WP_006521311.1 hypothetical protein -
DESGI_RS24140 4486284..4486667 + 384 WP_015618022.1 HNH endonuclease -
DESGI_RS20885 4486710..4486982 - 273 WP_006521309.1 type II toxin-antitoxin system YafQ family toxin Toxin
DESGI_RS20890 4486969..4487244 - 276 WP_006521308.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DESGI_RS23435 4487505..4488899 + 1395 WP_006521307.1 DNA modification methylase -
DESGI_RS20910 4488903..4490126 + 1224 WP_015618023.1 DNA modification methylase -
DESGI_RS20915 4490195..4490959 + 765 WP_006524197.1 hypothetical protein -
DESGI_RS20920 4490960..4491148 + 189 WP_006524198.1 hypothetical protein -
DESGI_RS20925 4491287..4492195 + 909 WP_006524199.1 amidoligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4461468..4538908 77440


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-82)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10602.39 Da        Isoelectric Point: 9.6107

>T29418 WP_006521309.1 NC_021184:c4486982-4486710 [Desulfallas gibsoniae DSM 7213]
MLKIRYSSRFKKDYKAIVKRGYDVKLLEEVLNILVQEKPLPQKYLDHPLSGNYGGHRECHITPDWLLIYKIEKDILTLSL
TRTGTHSDLF

Download         Length: 273 bp

>T29418 NC_021184:c4486982-4486710 [Desulfallas gibsoniae DSM 7213]
ATGCTGAAAATTAGATACTCCAGCCGCTTTAAAAAGGACTACAAAGCTATTGTTAAACGGGGCTATGATGTAAAACTGCT
GGAGGAAGTGTTAAATATTCTTGTCCAGGAGAAACCACTTCCTCAAAAATATCTTGACCACCCGCTTTCCGGTAATTACG
GTGGTCACCGTGAATGCCACATTACTCCTGACTGGCTGCTTATATACAAAATTGAAAAGGATATCCTGACCCTATCTTTA
ACCAGGACGGGAACCCACAGCGATTTATTCTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10319.59 Da        Isoelectric Point: 4.4563

>AT29418 WP_006521308.1 NC_021184:c4487244-4486969 [Desulfallas gibsoniae DSM 7213]
MAGTTNINVRVDKELKRKAEAIFNELGLNMSTAMNMFLRYSVRYGGIPFDLRLDTPNEETRAAIDDVNNNRNMSKTFDSV
DALMEDLNAEN

Download         Length: 276 bp

>AT29418 NC_021184:c4487244-4486969 [Desulfallas gibsoniae DSM 7213]
ATGGCCGGTACAACCAATATAAATGTTCGTGTCGATAAGGAATTAAAGCGTAAAGCTGAGGCTATCTTTAACGAGCTTGG
CCTCAACATGTCCACTGCTATGAATATGTTTTTGCGTTACTCCGTTCGTTACGGCGGCATTCCTTTTGACCTTCGCCTTG
ACACACCCAATGAGGAAACACGGGCCGCAATTGATGATGTTAATAACAACCGCAATATGAGCAAAACCTTTGACAGCGTA
GATGCCTTGATGGAGGATCTAAATGCTGAAAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A098B6E3

Antitoxin

Source ID Structure
AlphaFold DB A0A098B4Y9

References