Detailed information of TA system TA029417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2292448..2293001
• Replicon: chromosome
• Accession: NC_021184
• Organism: Desulfotomaculum gibsoniae DSM 7213

Toxin (Protein)

• Gene name: relE
• Uniprot ID: R4KMD1
• Locus tag: DESGI_RS10785
• Protein ID: WP_006522127.1
• Coordinates: 2292720..2293001 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4KGG4
• Locus tag: DESGI_RS10780
• Protein ID: WP_006522126.1
• Coordinates: 2292448..2292723 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DESGI_RS10755	2287587..2287925	+	339	WP_006522120.1	DUF86 domain-containing protein	-
DESGI_RS10760	2288514..2289446	-	933	WP_006522122.1	Rpn family recombination-promoting nuclease/putative transposase	-
DESGI_RS10765	2289683..2291164	-	1482	WP_006522123.1	FapA family protein	-
DESGI_RS24560	2291577..2291843	-	267	Protein_2143	PD-(D/E)XK nuclease family transposase	-
DESGI_RS10775	2291961..2292209	-	249	WP_006522125.1	hypothetical protein	-
DESGI_RS10780	2292448..2292723	+	276	WP_006522126.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DESGI_RS10785	2292720..2293001	+	282	WP_006522127.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DESGI_RS23815	2293046..2293723	-	678	Protein_2147	flagellin	-
DESGI_RS10795	2293797..2294216	-	420	WP_006522130.1	hypothetical protein	-
DESGI_RS25175	2294499..2294672	-	174	WP_006522131.1	hypothetical protein	-
DESGI_RS10800	2294898..2295836	-	939	WP_041285395.1	Rpn family recombination-promoting nuclease/putative transposase	-
DESGI_RS10805	2296689..2297528	-	840	WP_006522135.1	HNH endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (8-88)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11017.78 Da
• Isoelectric Point: 9.9234

>T29417 WP_006522127.1 NC_021184:2292720-2293001 [Desulfallas gibsoniae DSM 7213]
MKLDIVWTTQFKKDYKLAMKRGRNINLLDDIIRLLSRSEPLPEKNRDHALYGNWVGHRECHIQSNWLLVYRIENDILVLT
LVRTGSHSDLFGK

Nucleotide

• Length: 282 bp

>T29417 NC_021184:2292720-2293001 [Desulfallas gibsoniae DSM 7213]
ATGAAACTGGACATTGTTTGGACAACACAATTCAAGAAGGACTACAAGCTGGCAATGAAGCGCGGGCGTAACATCAATTT
GCTGGACGATATCATTCGCCTGCTTTCCAGGAGTGAACCGCTGCCGGAAAAAAACCGCGACCATGCGCTATACGGGAATT
GGGTGGGGCACCGGGAATGTCACATTCAAAGTAACTGGTTGCTTGTATACCGGATTGAAAATGACATTCTTGTGCTGACA
CTGGTACGTACCGGCTCTCACAGCGATTTGTTCGGCAAATAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10206.62 Da
• Isoelectric Point: 6.3139

>AT29417 WP_006522126.1 NC_021184:2292448-2292723 [Desulfallas gibsoniae DSM 7213]
VANTTNFSVRMDSEIKKQCEALYGELGMNLTTAINVFLRQSLRVGGFPFEVTINTPNAVTIAAMQEAERVARDPNAKRYS
DVEEALRELKR

Nucleotide

• Length: 276 bp

>AT29417 NC_021184:2292448-2292723 [Desulfallas gibsoniae DSM 7213]
GTGGCCAACACGACGAATTTCAGCGTCCGAATGGACAGCGAAATCAAGAAGCAGTGCGAGGCACTTTACGGAGAGCTTGG
CATGAATCTCACAACAGCCATCAACGTGTTTTTAAGACAGTCGCTTCGGGTCGGCGGTTTCCCGTTCGAGGTGACGATCA
ACACACCGAACGCCGTTACCATCGCTGCTATGCAGGAAGCCGAACGTGTTGCCCGCGACCCCAACGCAAAACGCTATAGC
GATGTAGAGGAAGCGTTGAGGGAGCTTAAAAGATGA

Structures

Toxin

• AlphaFold DB: R4KMD1

Antitoxin

• AlphaFold DB: R4KGG4