Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 959734..960263 Replicon chromosome
Accession NZ_LT992466
Organism Staphylococcus aureus isolate 4_LA_208

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE30_RS04775 Protein ID WP_000621175.1
Coordinates 959901..960263 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE30_RS04770 Protein ID WP_000948331.1
Coordinates 959734..959904 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE30_RS04740 954770..955330 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
DXE30_RS04745 955539..956018 + 480 WP_001287081.1 hypothetical protein -
DXE30_RS04750 956011..957588 + 1578 WP_001294650.1 PH domain-containing protein -
DXE30_RS04755 957581..958072 + 492 WP_001286980.1 PH domain-containing protein -
DXE30_RS04760 958076..958435 + 360 WP_000581197.1 holo-ACP synthase -
DXE30_RS04765 958501..959649 + 1149 WP_001281139.1 alanine racemase -
DXE30_RS04770 959734..959904 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE30_RS04775 959901..960263 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE30_RS04785 960613..961614 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE30_RS04790 961733..962059 + 327 WP_001052491.1 anti-sigma factor antagonist -
DXE30_RS04795 962061..962540 + 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE30_RS04800 962515..963285 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294169 WP_000621175.1 NZ_LT992466:959901-960263 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294169 WP_000948331.1 NZ_LT992466:959734-959904 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References