Detailed information of TA system TA029416

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2216623..2217071
• Replicon: chromosome
• Accession: NC_021184
• Organism: Desulfotomaculum gibsoniae DSM 7213

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: R4KEI4
• Locus tag: DESGI_RS10310
• Protein ID: WP_006522027.1
• Coordinates: 2216623..2216847 (-)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: R4KG80
• Locus tag: DESGI_RS10315
• Protein ID: WP_006522028.1
• Coordinates: 2216844..2217071 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DESGI_RS10295	2214250..2215104	-	855	WP_006522025.1	CoB--CoM heterodisulfide reductase iron-sulfur subunit B family protein	-
DESGI_RS10300	2215161..2215706	-	546	WP_157872906.1	4Fe-4S dicluster domain-containing protein	-
DESGI_RS10310	2216623..2216847	-	225	WP_006522027.1	type II toxin-antitoxin system HicA family toxin	Toxin
DESGI_RS10315	2216844..2217071	-	228	WP_006522028.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DESGI_RS10320	2217034..2217285	-	252	WP_006522029.1	helix-turn-helix transcriptional regulator	-
DESGI_RS10325	2217499..2217909	+	411	WP_006522030.1	hypothetical protein	-
DESGI_RS10330	2218121..2218369	-	249	WP_006522031.1	DUF1540 domain-containing protein	-
DESGI_RS10335	2218500..2219069	-	570	WP_006522032.1	HPP family protein	-
DESGI_RS10340	2219145..2219444	-	300	WP_006522033.1	hypothetical protein	-
DESGI_RS10345	2219628..2220020	-	393	WP_006522034.1	hypothetical protein	-
DESGI_RS10360	2220517..2220711	-	195	WP_006522035.1	hypothetical protein	-
DESGI_RS23810	2221285..2221377	-	93	WP_157872764.1	hypothetical protein	-
DESGI_RS10365	2221431..2221907	-	477	WP_006522037.1	PaaI family thioesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (9-65)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-62)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8057.59 Da
• Isoelectric Point: 11.0566

>T29416 WP_006522027.1 NC_021184:c2216847-2216623 [Desulfallas gibsoniae DSM 7213]
MTRMPRTTGKKVVTALKRAGFTVVRVTGSHHHLHKPGNKLVTVPVHAGETLSPILIKSILEQAGLTVEELIELL

Nucleotide

• Length: 225 bp

>T29416 NC_021184:c2216847-2216623 [Desulfallas gibsoniae DSM 7213]
ATGACGAGGATGCCCAGGACCACCGGCAAGAAGGTTGTAACAGCCCTCAAAAGAGCCGGCTTCACAGTGGTAAGAGTAAC
CGGCAGCCATCACCATTTACATAAGCCAGGGAATAAACTGGTAACAGTGCCCGTTCATGCAGGGGAGACATTAAGCCCAA
TATTAATCAAAAGCATTTTAGAACAAGCGGGCCTAACTGTTGAGGAATTAATTGAATTGTTATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8289.51 Da
• Isoelectric Point: 4.5125

>AT29416 WP_006522028.1 NC_021184:c2217071-2216844 [Desulfallas gibsoniae DSM 7213]
MPRKFKVILSWDNETQVYVVTVPALPGCVTQGKNREEALERIQEAITGHIEALKLIGEPVPQGDVEFAEVQVSVS

Nucleotide

• Length: 228 bp

>AT29416 NC_021184:c2217071-2216844 [Desulfallas gibsoniae DSM 7213]
ATGCCGCGCAAGTTCAAAGTTATCCTTTCCTGGGATAATGAAACACAGGTTTATGTTGTAACCGTTCCTGCCTTACCAGG
CTGTGTTACCCAGGGGAAGAACCGGGAAGAAGCATTGGAGCGTATCCAGGAAGCTATTACCGGCCATATTGAGGCCCTAA
AGTTAATTGGTGAGCCAGTCCCACAGGGAGACGTTGAATTTGCTGAAGTGCAGGTAAGTGTTTCATGA

Structures

Toxin

• AlphaFold DB: R4KEI4

Antitoxin

• AlphaFold DB: R4KG80