Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2422296..2422825 Replicon chromosome
Accession NZ_LT992465
Organism Staphylococcus aureus isolate 6_LA_232

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE62_RS12260 Protein ID WP_000621175.1
Coordinates 2422463..2422825 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE62_RS12255 Protein ID WP_000948331.1
Coordinates 2422296..2422466 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE62_RS12225 2417332..2417892 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
DXE62_RS12230 2418101..2418580 + 480 WP_001287081.1 hypothetical protein -
DXE62_RS12235 2418573..2420150 + 1578 WP_114637651.1 PH domain-containing protein -
DXE62_RS12240 2420143..2420634 + 492 WP_001286980.1 PH domain-containing protein -
DXE62_RS12245 2420638..2420997 + 360 WP_000581197.1 holo-ACP synthase -
DXE62_RS12250 2421063..2422211 + 1149 WP_001281139.1 alanine racemase -
DXE62_RS12255 2422296..2422466 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE62_RS12260 2422463..2422825 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE62_RS12270 2423175..2424176 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE62_RS12275 2424295..2424621 + 327 WP_001052491.1 anti-sigma factor antagonist -
DXE62_RS12280 2424623..2425102 + 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE62_RS12285 2425077..2425847 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294159 WP_000621175.1 NZ_LT992465:2422463-2422825 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294159 WP_000948331.1 NZ_LT992465:2422296-2422466 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References