Detailed information of TA system TA029415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1244376..1244920
• Replicon: chromosome
• Accession: NC_021184
• Organism: Desulfotomaculum gibsoniae DSM 7213

Toxin (Protein)

• Gene name: relE
• Uniprot ID: R4KC10
• Locus tag: DESGI_RS05715
• Protein ID: WP_006523748.1
• Coordinates: 1244654..1244920 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4KGD9
• Locus tag: DESGI_RS05710
• Protein ID: WP_006523747.1
• Coordinates: 1244376..1244651 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DESGI_RS05705	1240478..1244134	+	3657	WP_006523746.1	BREX-1 system adenine-specific DNA-methyltransferase PglX	-
DESGI_RS05710	1244376..1244651	+	276	WP_006523747.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DESGI_RS05715	1244654..1244920	+	267	WP_006523748.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
DESGI_RS05720	1245010..1247532	+	2523	WP_006523749.1	BREX-1 system phosphatase PglZ type A	-
DESGI_RS05725	1247545..1247730	+	186	WP_006523750.1	hypothetical protein	-
DESGI_RS23650	1247666..1247971	+	306	WP_157872739.1	hypothetical protein	-
DESGI_RS05730	1248655..1248900	-	246	WP_006523752.1	type II toxin-antitoxin system MqsA family antitoxin	-
DESGI_RS23655	1248902..1249099	-	198	WP_083939770.1	DUF4258 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-90)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10393.19 Da
• Isoelectric Point: 8.5187

>T29415 WP_006523748.1 NC_021184:1244654-1244920 [Desulfallas gibsoniae DSM 7213]
MLIPEYTNRFKKDLKAIQKRNWDIHLLKEVLMLLCAEIPLQEKYKDHALRGNWAGHRVCHIQPDWLLIYQVGNGLLVLER
TGSHSDLF

Nucleotide

• Length: 267 bp

>T29415 NC_021184:1244654-1244920 [Desulfallas gibsoniae DSM 7213]
ATGCTGATACCGGAATATACTAATAGATTTAAAAAAGATCTGAAGGCCATTCAAAAGAGAAATTGGGATATTCATCTCTT
AAAAGAAGTTCTCATGCTATTATGTGCGGAAATACCCTTGCAAGAAAAATATAAAGATCATGCATTAAGGGGTAATTGGG
CAGGCCATAGGGTATGTCATATACAACCAGATTGGCTGCTTATTTACCAAGTGGGTAATGGTTTACTTGTCCTTGAACGA
ACGGGGTCGCACAGTGACTTGTTTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10258.76 Da
• Isoelectric Point: 4.6151

>AT29415 WP_006523747.1 NC_021184:1244376-1244651 [Desulfallas gibsoniae DSM 7213]
MANDTTNLNIRMDVELKKQAEELFSELGMNMTTAINIFLRQAVRQGSIPFAIKLNDPNAETVAAMKEGEDIIKSGKSRFY
NTEEMFKDLGI

Nucleotide

• Length: 276 bp

>AT29415 NC_021184:1244376-1244651 [Desulfallas gibsoniae DSM 7213]
ATGGCGAATGACACAACTAATTTAAATATCCGTATGGATGTAGAACTCAAGAAACAAGCGGAAGAGCTATTTTCTGAGTT
AGGAATGAATATGACGACTGCAATTAATATATTTTTACGACAGGCTGTAAGACAGGGAAGCATACCTTTTGCGATAAAAC
TTAATGATCCCAATGCTGAAACAGTTGCTGCTATGAAAGAGGGCGAGGATATTATTAAGTCCGGCAAAAGCAGATTTTAT
AATACAGAAGAAATGTTTAAAGATTTAGGTATTTAG

Structures

Toxin

• AlphaFold DB: R4KC10

Antitoxin

• AlphaFold DB: R4KGD9