294146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2314608..2315396 Replicon chromosome
Accession NZ_LT992464
Organism Staphylococcus aureus isolate 3_LA_115

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag DXE56_RS12325 Protein ID WP_000525004.1
Coordinates 2314935..2315396 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag DXE56_RS12320 Protein ID WP_000333630.1
Coordinates 2314608..2314922 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE56_RS12260 2309750..2310916 - 1167 WP_000762545.1 DUF2800 domain-containing protein -
DXE56_RS12265 2310913..2311275 - 363 WP_000985976.1 hypothetical protein -
DXE56_RS12270 2311290..2311613 - 324 WP_000174994.1 hypothetical protein -
DXE56_RS12275 2311692..2311853 - 162 WP_001285963.1 DUF1270 family protein -
DXE56_RS12280 2311866..2312129 - 264 WP_001124190.1 helix-turn-helix domain-containing protein -
DXE56_RS12285 2312154..2312369 - 216 WP_001036302.1 hypothetical protein -
DXE56_RS12290 2312424..2312789 + 366 WP_001128433.1 hypothetical protein -
DXE56_RS12295 2312758..2313003 - 246 WP_001025401.1 DUF2829 domain-containing protein -
DXE56_RS12300 2313059..2313268 + 210 WP_000642492.1 hypothetical protein -
DXE56_RS12305 2313258..2313401 - 144 WP_000939498.1 hypothetical protein -
DXE56_RS12310 2313430..2314206 - 777 WP_001148544.1 Rha family transcriptional regulator -
DXE56_RS12315 2314220..2314456 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
DXE56_RS12320 2314608..2314922 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
DXE56_RS12325 2314935..2315396 + 462 WP_000525004.1 hypothetical protein Toxin
DXE56_RS12330 2315414..2315998 + 585 WP_000825948.1 hypothetical protein -
DXE56_RS12335 2316228..2316374 + 147 WP_001013104.1 hypothetical protein -
DXE56_RS12340 2316371..2316985 - 615 WP_000191461.1 hypothetical protein -
DXE56_RS12345 2317095..2318300 + 1206 WP_000264185.1 site-specific integrase -
DXE56_RS12350 2318394..2320328 - 1935 Protein_2276 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - geh 2273235..2329804 56569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T294146 WP_000525004.1 NZ_LT992464:2314935-2315396 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT294146 WP_000333630.1 NZ_LT992464:2314608-2314922 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References