Detailed information of TA system TA029413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2500457..2501021
• Replicon: chromosome
• Accession: NC_021177
• Organism: Streptomyces fulvissimus DSM 40593

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: N0CVY2
• Locus tag: SFUL_RS10985
• Protein ID: WP_015608543.1
• Coordinates: 2500457..2500804 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: N0CUB8
• Locus tag: SFUL_RS10990
• Protein ID: WP_015608544.1
• Coordinates: 2500797..2501021 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFUL_RS10975	2495771..2499079	+	3309	WP_209440394.1	S8 family serine peptidase	-
SFUL_RS10980	2499350..2500378	+	1029	WP_015608542.1	aspartate-semialdehyde dehydrogenase	-
SFUL_RS10985	2500457..2500804	-	348	WP_015608543.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SFUL_RS10990	2500797..2501021	-	225	WP_015608544.1	ribbon-helix-helix domain-containing protein	Antitoxin
SFUL_RS10995	2501125..2503701	+	2577	WP_043972136.1	aminopeptidase N	-
SFUL_RS11000	2503878..2504408	+	531	WP_015608546.1	hypothetical protein	-
SFUL_RS11005	2504498..2505652	-	1155	WP_015608547.1	allantoicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12763.66 Da
• Isoelectric Point: 11.7286

>T29413 WP_015608543.1 NC_021177:c2500804-2500457 [Streptomyces fulvissimus DSM 40593]
MRRGDIHLVDLEPARGSEANKARPAVIVSNNAANRSAEVSGRGVVAVVPLTSNTSRILSFQVLLTTEESRFPQNSKVQCE
QIRAVSPDRILKRLGEVPRQRMAEIDRALRRHLAL

Nucleotide

• Length: 348 bp

>T29413 NC_021177:c2500804-2500457 [Streptomyces fulvissimus DSM 40593]
ATGCGTAGGGGCGACATCCACCTCGTGGACCTGGAGCCCGCACGGGGGAGCGAAGCCAACAAGGCGCGTCCGGCGGTGAT
CGTCTCCAACAACGCCGCCAACCGGTCGGCCGAGGTGTCCGGCAGGGGCGTCGTCGCCGTGGTGCCGCTGACCTCGAACA
CCTCGCGGATCCTCAGTTTCCAGGTGCTTCTCACCACGGAGGAGAGCCGCTTCCCGCAGAACTCCAAGGTCCAGTGCGAA
CAGATCCGGGCGGTGTCCCCCGACCGGATCCTGAAGCGCCTCGGTGAGGTGCCCCGCCAGCGCATGGCGGAGATCGACAG
AGCTCTGCGCCGGCACCTGGCTCTCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8061.79 Da
• Isoelectric Point: 3.7720

>AT29413 WP_015608544.1 NC_021177:c2501021-2500797 [Streptomyces fulvissimus DSM 40593]
MKISVSLPQEDVAFVDEYAAKTDADSRSAVIHAAIELLRTAGLEAEYTEAFQEWDASEDAALWDRTVADGLTDA

Nucleotide

• Length: 225 bp

>AT29413 NC_021177:c2501021-2500797 [Streptomyces fulvissimus DSM 40593]
ATGAAGATCAGTGTGAGTCTGCCGCAGGAGGATGTCGCCTTCGTCGACGAATACGCGGCGAAGACCGACGCGGATTCCCG
GTCCGCCGTCATACACGCCGCTATCGAGTTGCTGCGTACCGCGGGCCTGGAGGCGGAGTACACCGAGGCGTTCCAGGAAT
GGGACGCGAGTGAGGACGCCGCTCTGTGGGACCGCACAGTGGCCGACGGGCTCACAGATGCGTAG

Structures

Toxin

• AlphaFold DB: N0CVY2

Antitoxin

• AlphaFold DB: N0CUB8