294122

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2299716..2300245 Replicon chromosome
Accession NZ_LT992463
Organism Staphylococcus aureus isolate 2_LA_86

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE29_RS11650 Protein ID WP_000621175.1
Coordinates 2299716..2300078 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE29_RS11655 Protein ID WP_000948331.1
Coordinates 2300075..2300245 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE29_RS11625 2296694..2297464 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
DXE29_RS11630 2297439..2297918 - 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE29_RS11635 2297920..2298246 - 327 WP_001052491.1 anti-sigma factor antagonist -
DXE29_RS11640 2298365..2299366 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE29_RS11650 2299716..2300078 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE29_RS11655 2300075..2300245 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE29_RS11660 2300330..2301478 - 1149 WP_001281139.1 alanine racemase -
DXE29_RS11665 2301544..2301903 - 360 WP_000581197.1 holo-ACP synthase -
DXE29_RS11670 2301907..2302398 - 492 WP_001286980.1 PH domain-containing protein -
DXE29_RS11675 2302391..2303968 - 1578 WP_001294650.1 PH domain-containing protein -
DXE29_RS11680 2303961..2304440 - 480 WP_001287081.1 hypothetical protein -
DXE29_RS11685 2304649..2305209 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294122 WP_000621175.1 NZ_LT992463:c2300078-2299716 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294122 WP_000948331.1 NZ_LT992463:c2300245-2300075 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References