Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1881987..1882516 Replicon chromosome
Accession NZ_LT992462
Organism Staphylococcus aureus isolate 5_3949

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE65_RS10075 Protein ID WP_000621175.1
Coordinates 1881987..1882349 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE65_RS10080 Protein ID WP_000948331.1
Coordinates 1882346..1882516 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE65_RS10050 1878965..1879735 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
DXE65_RS10055 1879710..1880189 - 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE65_RS10060 1880191..1880517 - 327 WP_001052491.1 anti-sigma factor antagonist -
DXE65_RS10065 1880636..1881637 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE65_RS10075 1881987..1882349 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE65_RS10080 1882346..1882516 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE65_RS10085 1882601..1883749 - 1149 WP_001281139.1 alanine racemase -
DXE65_RS10090 1883815..1884174 - 360 WP_000581197.1 holo-ACP synthase -
DXE65_RS10095 1884178..1884669 - 492 WP_001286980.1 PH domain-containing protein -
DXE65_RS10100 1884662..1886239 - 1578 WP_001294650.1 PH domain-containing protein -
DXE65_RS10105 1886232..1886711 - 480 WP_031914465.1 membrane protein -
DXE65_RS10110 1886920..1887480 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294109 WP_000621175.1 NZ_LT992462:c1882349-1881987 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294109 WP_000948331.1 NZ_LT992462:c1882516-1882346 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References