Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1323106..1323903 Replicon chromosome
Accession NZ_LT992461
Organism Staphylococcus aureus isolate 8_LA_272

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag DXE60_RS06970 Protein ID WP_031838007.1
Coordinates 1323106..1323567 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag DXE60_RS06975 Protein ID WP_001260485.1
Coordinates 1323580..1323903 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE60_RS06945 1320052..1321257 - 1206 WP_000264745.1 site-specific integrase -
DXE60_RS06950 1321383..1321997 + 615 WP_000191466.1 hypothetical protein -
DXE60_RS06955 1321994..1322140 - 147 WP_074370993.1 hypothetical protein -
DXE60_RS06960 1322230..1322625 - 396 WP_000449655.1 hypothetical protein -
DXE60_RS06965 1322654..1323088 - 435 WP_000755718.1 hypothetical protein -
DXE60_RS06970 1323106..1323567 - 462 WP_031838007.1 toxin Toxin
DXE60_RS06975 1323580..1323903 - 324 WP_001260485.1 helix-turn-helix domain-containing protein Antitoxin
DXE60_RS06980 1324067..1324315 + 249 WP_000272860.1 helix-turn-helix domain-containing protein -
DXE60_RS06985 1324331..1324576 + 246 WP_001025401.1 DUF2829 domain-containing protein -
DXE60_RS06990 1324545..1324910 - 366 WP_001128433.1 hypothetical protein -
DXE60_RS06995 1324965..1325180 + 216 WP_001036302.1 hypothetical protein -
DXE60_RS07000 1325205..1325468 + 264 WP_001124190.1 helix-turn-helix domain-containing protein -
DXE60_RS07005 1325481..1325642 + 162 WP_001285963.1 DUF1270 family protein -
DXE60_RS07010 1325721..1326044 + 324 WP_000174994.1 hypothetical protein -
DXE60_RS07015 1326059..1326421 + 363 WP_031775157.1 hypothetical protein -
DXE60_RS07020 1326418..1327584 + 1167 WP_000762547.1 DUF2800 domain-containing protein -
DXE60_RS07025 1327610..1328167 + 558 WP_000645042.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1320052..1364093 44041


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18006.39 Da        Isoelectric Point: 4.9167

>T294092 WP_031838007.1 NZ_LT992461:c1323567-1323106 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12439.16 Da        Isoelectric Point: 9.3811

>AT294092 WP_001260485.1 NZ_LT992461:c1323903-1323580 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References