Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 290525..291039 Replicon chromosome
Accession NZ_LT992461
Organism Staphylococcus aureus isolate 8_LA_272

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DXE60_RS01805 Protein ID WP_000581792.1
Coordinates 290525..290734 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DXE60_RS01810 Protein ID WP_000138932.1
Coordinates 290746..291039 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE60_RS01785 286036..287391 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DXE60_RS01790 287406..288476 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
DXE60_RS01795 288794..289996 + 1203 WP_001109939.1 rod shape-determining protein RodA -
DXE60_RS01800 290260..290397 - 138 WP_000828354.1 hypothetical protein -
DXE60_RS01805 290525..290734 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DXE60_RS01810 290746..291039 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DXE60_RS01815 291205..292689 + 1485 WP_000571550.1 cardiolipin synthase -
DXE60_RS01820 292717..293364 + 648 WP_001187614.1 HD domain-containing protein -
DXE60_RS01825 293644..293964 + 321 WP_001825748.1 hypothetical protein -
DXE60_RS01830 293961..295276 - 1316 Protein_309 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T294088 WP_000581792.1 NZ_LT992461:c290734-290525 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT294088 WP_000138932.1 NZ_LT992461:c291039-290746 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References