294078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1648105..1648634 Replicon chromosome
Accession NZ_LT992460
Organism Staphylococcus aureus isolate 9_LA_281

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE39_RS08540 Protein ID WP_000621175.1
Coordinates 1648272..1648634 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE39_RS08535 Protein ID WP_000948331.1
Coordinates 1648105..1648275 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE39_RS08505 1643141..1643701 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
DXE39_RS08510 1643910..1644389 + 480 WP_001287081.1 hypothetical protein -
DXE39_RS08515 1644382..1645959 + 1578 WP_001294650.1 PH domain-containing protein -
DXE39_RS08520 1645952..1646443 + 492 WP_001286980.1 PH domain-containing protein -
DXE39_RS08525 1646447..1646806 + 360 WP_000581197.1 holo-ACP synthase -
DXE39_RS08530 1646872..1648020 + 1149 WP_001281139.1 alanine racemase -
DXE39_RS08535 1648105..1648275 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE39_RS08540 1648272..1648634 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE39_RS08550 1648984..1649985 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE39_RS08555 1650104..1650430 + 327 WP_001052491.1 anti-sigma factor antagonist -
DXE39_RS08560 1650432..1650911 + 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE39_RS08565 1650886..1651656 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294078 WP_000621175.1 NZ_LT992460:1648272-1648634 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294078 WP_000948331.1 NZ_LT992460:1648105-1648275 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References