Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1514481..1515257 Replicon chromosome
Accession NZ_LT992458
Organism Staphylococcus aureus isolate 7_4623

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DXE63_RS08045 Protein ID WP_000031108.1
Coordinates 1515105..1515257 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DXE63_RS08040 Protein ID WP_001251224.1
Coordinates 1514481..1515080 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE63_RS08020 1510397..1511854 + 1458 WP_000649908.1 ABC transporter permease subunit -
DXE63_RS08025 1511847..1512569 + 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
DXE63_RS08030 1512720..1513847 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
DXE63_RS08035 1513852..1514322 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DXE63_RS08040 1514481..1515080 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
DXE63_RS08045 1515105..1515257 + 153 WP_000031108.1 hypothetical protein Toxin
DXE63_RS08055 1515800..1516195 + 396 WP_000901018.1 hypothetical protein -
DXE63_RS08060 1516391..1517776 + 1386 WP_000116238.1 class II fumarate hydratase -
DXE63_RS08065 1518231..1519052 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T294062 WP_000031108.1 NZ_LT992458:1515105-1515257 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT294062 WP_001251224.1 NZ_LT992458:1514481-1515080 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References