Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1290182..1290696 Replicon chromosome
Accession NZ_LT992458
Organism Staphylococcus aureus isolate 7_4623

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DXE63_RS06630 Protein ID WP_000581792.1
Coordinates 1290487..1290696 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DXE63_RS06625 Protein ID WP_000138932.1
Coordinates 1290182..1290475 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE63_RS06605 1285945..1287260 + 1316 Protein_1227 ISL3 family transposase -
DXE63_RS06610 1287257..1287577 - 321 WP_001825748.1 hypothetical protein -
DXE63_RS06615 1287857..1288504 - 648 WP_001187614.1 HD domain-containing protein -
DXE63_RS06620 1288532..1290016 - 1485 WP_000571550.1 cardiolipin synthase -
DXE63_RS06625 1290182..1290475 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DXE63_RS06630 1290487..1290696 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DXE63_RS06635 1290824..1290961 + 138 WP_000828354.1 hypothetical protein -
DXE63_RS06640 1291225..1292427 - 1203 WP_001109939.1 rod shape-determining protein RodA -
DXE63_RS06645 1292745..1293815 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
DXE63_RS06650 1293830..1295185 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T294056 WP_000581792.1 NZ_LT992458:1290487-1290696 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT294056 WP_000138932.1 NZ_LT992458:1290182-1290475 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References