294051

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 240360..241157 Replicon chromosome
Accession NZ_LT992458
Organism Staphylococcus aureus isolate 7_4623

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag DXE63_RS01380 Protein ID WP_031838007.1
Coordinates 240696..241157 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag DXE63_RS01375 Protein ID WP_001260485.1
Coordinates 240360..240683 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE63_RS01325 236096..236653 - 558 WP_000645042.1 DUF2815 family protein -
DXE63_RS01330 236679..237845 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
DXE63_RS01335 237842..238204 - 363 WP_031775157.1 hypothetical protein -
DXE63_RS01340 238219..238542 - 324 WP_000174994.1 hypothetical protein -
DXE63_RS01345 238621..238782 - 162 WP_001285963.1 DUF1270 family protein -
DXE63_RS01350 238795..239058 - 264 WP_001124190.1 helix-turn-helix domain-containing protein -
DXE63_RS01355 239083..239298 - 216 WP_001036302.1 hypothetical protein -
DXE63_RS01360 239353..239718 + 366 WP_001128433.1 hypothetical protein -
DXE63_RS01365 239687..239932 - 246 WP_001025401.1 DUF2829 domain-containing protein -
DXE63_RS01370 239948..240196 - 249 WP_000272860.1 helix-turn-helix domain-containing protein -
DXE63_RS01375 240360..240683 + 324 WP_001260485.1 helix-turn-helix domain-containing protein Antitoxin
DXE63_RS01380 240696..241157 + 462 WP_031838007.1 toxin Toxin
DXE63_RS01385 241175..241609 + 435 WP_000755718.1 hypothetical protein -
DXE63_RS01390 241638..242033 + 396 WP_000449655.1 hypothetical protein -
DXE63_RS01395 242123..242269 + 147 WP_074370993.1 hypothetical protein -
DXE63_RS01400 242266..242880 - 615 WP_000191466.1 hypothetical protein -
DXE63_RS01405 243006..244211 + 1206 WP_000264745.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 200170..244211 44041


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18006.39 Da        Isoelectric Point: 4.9167

>T294051 WP_031838007.1 NZ_LT992458:240696-241157 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12439.16 Da        Isoelectric Point: 9.3811

>AT294051 WP_001260485.1 NZ_LT992458:240360-240683 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References