Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 2005341..2005870 | Replicon | chromosome |
Accession | NZ_LT992456 | ||
Organism | Staphylococcus aureus isolate 1_1439 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | - |
Locus tag | DXE58_RS10165 | Protein ID | WP_000621175.1 |
Coordinates | 2005508..2005870 (+) | Length | 121 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | T1YCG8 |
Locus tag | DXE58_RS10160 | Protein ID | WP_000948331.1 |
Coordinates | 2005341..2005511 (+) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DXE58_RS10130 | 2000377..2000937 | + | 561 | WP_001092419.1 | K(+)-transporting ATPase subunit C | - |
DXE58_RS10135 | 2001146..2001625 | + | 480 | WP_001287081.1 | hypothetical protein | - |
DXE58_RS10140 | 2001618..2003195 | + | 1578 | WP_114668449.1 | PH domain-containing protein | - |
DXE58_RS10145 | 2003188..2003679 | + | 492 | WP_001286980.1 | PH domain-containing protein | - |
DXE58_RS10150 | 2003683..2004042 | + | 360 | WP_000581197.1 | holo-ACP synthase | - |
DXE58_RS10155 | 2004108..2005256 | + | 1149 | WP_001281139.1 | alanine racemase | - |
DXE58_RS10160 | 2005341..2005511 | + | 171 | WP_000948331.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
DXE58_RS10165 | 2005508..2005870 | + | 363 | WP_000621175.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
DXE58_RS10175 | 2006220..2007221 | + | 1002 | WP_000390829.1 | PP2C family protein-serine/threonine phosphatase | - |
DXE58_RS10180 | 2007340..2007666 | + | 327 | WP_001052491.1 | anti-sigma factor antagonist | - |
DXE58_RS10185 | 2007668..2008147 | + | 480 | WP_001190825.1 | anti-sigma B factor RsbW | - |
DXE58_RS10190 | 2008122..2008892 | + | 771 | WP_001041107.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13441.69 Da Isoelectric Point: 10.1654
>T294041 WP_000621175.1 NZ_LT992456:2005508-2005870 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
Download Length: 363 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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