Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 894262..895505 Replicon chromosome
Accession NC_021175
Organism Streptococcus oligofermentans AS 1.3089

Toxin (Protein)


Gene name sezT Uniprot ID A0A512A940
Locus tag I872_RS04335 Protein ID WP_015604931.1
Coordinates 894738..895505 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID A0A512A997
Locus tag I872_RS04330 Protein ID WP_015604930.1
Coordinates 894262..894738 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I872_RS04310 889567..889749 - 183 WP_197712457.1 DUF3173 domain-containing protein -
I872_RS04315 890021..891382 - 1362 WP_015604928.1 hypothetical protein -
I872_RS04320 891798..892809 - 1012 Protein_830 site-specific integrase -
I872_RS04325 893682..894044 + 363 WP_000479225.1 hypothetical protein -
I872_RS04330 894262..894738 + 477 WP_015604930.1 helix-turn-helix domain-containing protein Antitoxin
I872_RS04335 894738..895505 + 768 WP_015604931.1 zeta toxin family protein Toxin
I872_RS04340 895864..896097 + 234 WP_006145693.1 hypothetical protein -
I872_RS04345 896118..896672 + 555 WP_015604932.1 hypothetical protein -
I872_RS04350 896742..897164 + 423 WP_015604933.1 hypothetical protein -
I872_RS04355 897306..897638 + 333 Protein_837 hypothetical protein -
I872_RS10880 897648..897968 + 321 Protein_838 hypothetical protein -
I872_RS12080 897987..898297 + 311 Protein_839 hypothetical protein -
I872_RS04370 898321..898653 + 333 WP_015604936.1 hypothetical protein -
I872_RS04375 898706..899179 + 474 WP_015604937.1 SMI1/KNR4 family protein -
I872_RS04380 899269..899604 + 336 WP_015604938.1 hypothetical protein -
I872_RS04385 899646..900047 + 402 WP_015604939.1 hypothetical protein -
I872_RS04390 900093..900443 + 351 WP_015604940.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 789608..920619 131011


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29217.98 Da        Isoelectric Point: 6.1697

>T29404 WP_015604931.1 NC_021175:894738-895505 [Streptococcus cristatus AS 1.3089]
MKLEEFSQDDFERASRRLVRSLTRGKTTSSHPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPRKTAQLLATRGYQVSLALIATKPELSYLSTLIRYEE
LYAIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCVYDSQVDGTSAAEVLQECLFGKWSKVEEEML
NWGQERLRELGEIDK

Download         Length: 768 bp

>T29404 NC_021175:894738-895505 [Streptococcus cristatus AS 1.3089]
ATGAAACTAGAAGAATTTAGTCAAGATGATTTTGAACGAGCATCCAGACGACTCGTTCGTTCTTTAACTCGTGGTAAAAC
AACCTCATCTCATCCTAAGGCTATTTTGCTCGGTGGACAGAGTGGTGCTGGGAAAACAACGATTCATCGTATTAAACAAA
GGGAATTTCAAGGTAATATCATTATCATTGATGGAGATAGTTATCGCTCTTTTCATCCGAACTACCTTGGCCTACAGGAA
AAGTATGGCAAAGATAGTGTAGATTATACCAAAGTGTTTGCGGGACAAATGGTTGAATATCTTGTAGATGAGTTGAGTAA
AAAAGGTTATCATTTGTTAATCGAGGGTACCTTGAGAACAACAGAAGTTCCCCGAAAAACGGCCCAATTATTGGCAACTA
GAGGATATCAAGTCTCACTTGCACTGATTGCGACCAAGCCAGAATTGTCTTATCTCAGTACCTTGATTCGTTATGAGGAG
CTCTACGCCATAGATCCTAGTCAAGCAAGGGCGACTCCCAAAGAGCACCATGATGGAATTGTAGAACATTTAGTTGATAA
CTTACGAGAGTTAGAAAATGACAAAATTTTTAATCAAATTCAAATTTATCAAAGAGATCAATCGTGTGTTTATGATTCGC
AAGTAGACGGAACCTCAGCAGCAGAAGTTCTACAAGAATGCCTATTTGGAAAATGGAGTAAGGTGGAGGAAGAAATGTTG
AATTGGGGACAGGAACGGTTGAGAGAGTTGGGGGAAATTGATAAGTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18065.51 Da        Isoelectric Point: 4.4367

>AT29404 WP_015604930.1 NC_021175:894262-894738 [Streptococcus cristatus AS 1.3089]
MIGENIKTLRKAHNLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLINTRIYLVATFEDIERFNGYLDGIERMLEQASHLVVA

Download         Length: 477 bp

>AT29404 NC_021175:894262-894738 [Streptococcus cristatus AS 1.3089]
ATGATTGGAGAAAATATAAAAACGTTACGCAAGGCACATAACCTAACTCAGCCTGAGTTCGCAAAGATTGTTGGTATCTC
TCGAAATAGCCTAAGTCGTTATGAAAATGGAACAAGTTCAGTTTCGACAGAATTAATAGATCGTATCTGCCAGAAATTTA
ATGTTTCCTATATCGATATCGTAGGAGAGGAAAAGATGCTCACACCAGTAGAAGATTACCAGTTGACCCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTTCAAGATGAGCAAGGAATTGCATTTGATGATAC
TTCTAATCCTTGGGTTCTAATGAGCGATGATTTGTCTGATTTAATTAACACGAGGATTTATCTTGTTGCAACTTTTGAGG
ATATAGAGCGATTTAATGGCTATTTGGATGGCATTGAACGTATGCTAGAACAAGCTAGTCATCTGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A512A940

Antitoxin

Source ID Structure
AlphaFold DB A0A512A997

References