Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2596685..2598450 Replicon chromosome
Accession NC_021174
Organism Burkholderia thailandensis MSMB121

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BTI_RS28555 Protein ID WP_015602947.1
Coordinates 2596685..2597599 (+) Length 305 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag BTI_RS28560 Protein ID WP_015603863.1
Coordinates 2597596..2598450 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTI_RS28525 2592079..2593167 - 1089 WP_009914825.1 porin -
BTI_RS28530 2593603..2593920 + 318 WP_009914826.1 non-heme iron oxygenase ferredoxin subunit -
BTI_RS28535 2593922..2594233 + 312 WP_006027427.1 hypothetical protein -
BTI_RS28540 2594268..2595335 + 1068 WP_015603807.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BTI_RS28545 2595332..2596102 + 771 WP_015603778.1 SDR family oxidoreductase -
BTI_RS28550 2596141..2596668 + 528 WP_015603157.1 cupin domain-containing protein -
BTI_RS28555 2596685..2597599 + 915 WP_015602947.1 alpha/beta fold hydrolase Toxin
BTI_RS28560 2597596..2598450 + 855 WP_015603863.1 IclR family transcriptional regulator Antitoxin
BTI_RS28565 2598447..2599244 + 798 WP_015602774.1 SDR family oxidoreductase -
BTI_RS28570 2599237..2600910 + 1674 WP_015604105.1 thiamine pyrophosphate-binding protein -
BTI_RS28575 2600903..2601718 + 816 WP_015603755.1 aspartate dehydrogenase -
BTI_RS28580 2601744..2603234 + 1491 WP_015603069.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(57-287)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 305 a.a.        Molecular weight: 31189.09 Da        Isoelectric Point: 7.1483

>T29402 WP_015602947.1 NC_021174:2596685-2597599 [Burkholderia thailandensis MSMB121]
MSAISTTTAGASAMPFAALLERFAERHAAAGDAGTIGYREAGESYGERTEQAGRDPVVLLHGIGSGAASWVRQLDALGAT
RRALAWDAPGYGASSRVAAGSPVAADYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARIASERLAGLLLISPAGGYGG
TPADVRAERRDSRLALLASLGPQGLADERSANLLSAHASDTARAWVHWNMARIAPAGYAQATHLLANADLASDLVHYRGR
VAVAVGGDDAITPPAACERIARAARVGLQVIPRAGHAGYVEAPDAYSALIDAFCRQCDGSRGAT

Download         Length: 915 bp

>T29402 NC_021174:2596685-2597599 [Burkholderia thailandensis MSMB121]
ATGAGCGCGATTTCCACGACGACAGCCGGCGCGAGCGCGATGCCTTTCGCCGCGCTGCTCGAACGCTTCGCCGAGCGACA
CGCGGCGGCGGGCGACGCGGGCACGATCGGCTACCGCGAGGCGGGCGAATCGTACGGCGAGCGCACTGAGCAAGCCGGGC
GCGATCCCGTCGTGCTGCTGCACGGGATCGGATCGGGTGCGGCGTCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCGACG
CGTCGCGCGCTCGCGTGGGACGCGCCAGGCTATGGCGCATCGTCACGCGTCGCGGCCGGCTCGCCCGTCGCGGCCGACTA
CGCGGCGTCGCTCGCCGCGTGGCTCGACGCGCTGCGCATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCG
TCGCCGGCGCGTTCGCGCGGATCGCGAGCGAGCGGCTTGCGGGATTGCTGCTGATTTCTCCTGCCGGCGGCTACGGCGGC
ACGCCCGCCGACGTGCGGGCCGAGCGGCGCGACAGCCGTCTCGCACTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGA
CGAGCGCAGCGCAAACCTGTTGTCCGCGCATGCGAGCGACACGGCGCGCGCGTGGGTGCACTGGAACATGGCGCGCATCG
CGCCCGCCGGCTATGCGCAGGCGACGCATCTGCTCGCGAACGCGGATCTCGCGTCCGATCTCGTCCATTACCGCGGCCGC
GTCGCGGTCGCCGTCGGCGGCGACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATTGCGCGCGCGGCGCGTGTTGG
GCTGCAGGTGATTCCCCGTGCGGGCCATGCCGGCTACGTTGAAGCGCCCGATGCGTACAGTGCGTTGATCGACGCTTTTT
GCCGTCAATGCGACGGATCGCGAGGCGCGACATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31015.47 Da        Isoelectric Point: 7.4665

>AT29402 WP_015603863.1 NC_021174:2597596-2598450 [Burkholderia thailandensis MSMB121]
MSEPLLKDADNAKNDSNYVVPGLERGLRVLAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAELRALYPERELERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVADGLIEKVVRAAGGLSRRLNYRADDENTYLKALGLR

Download         Length: 855 bp

>AT29402 NC_021174:2597596-2598450 [Burkholderia thailandensis MSMB121]
ATGAGCGAACCGCTGCTGAAGGACGCCGACAACGCGAAGAATGATTCGAACTACGTAGTACCGGGGCTCGAGCGCGGGCT
GCGGGTCCTGGCCGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAGTCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAATTATCGCCTC
GGCGTCGCGGTGTTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACTGATCTCGGCTTGCCGGTGATAGAAGG
CTTGCGCGATGCGACGGGCTTCACGGCGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCACGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCCGAGTTGCGCGCGCTGTATCCGGAGCGGGAGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACTGTCGACGCGCTCTTCGACGTGATTCGCGCCGATGCGCGGCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGAGGCGAGCCGGATCGTCGCGGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGATGCGGCGCTCGTCGCCGACGGGCTGATCGAGAAGGTCGTGCGCGCGGCGGGCGGACTGTCGCGGCGGCT
CAACTACCGGGCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References