Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1083858..1084387 Replicon chromosome
Accession NZ_LT992435
Organism Staphylococcus aureus isolate 1549-SCV

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DYY96_RS05675 Protein ID WP_000621175.1
Coordinates 1083858..1084220 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DYY96_RS05680 Protein ID WP_000948331.1
Coordinates 1084217..1084387 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYY96_RS05650 1080837..1081607 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
DYY96_RS05655 1081582..1082061 - 480 WP_001190825.1 anti-sigma B factor RsbW -
DYY96_RS05660 1082063..1082389 - 327 WP_001052491.1 anti-sigma factor antagonist -
DYY96_RS05665 1082508..1083509 - 1002 WP_042744356.1 PP2C family protein-serine/threonine phosphatase -
DYY96_RS05675 1083858..1084220 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DYY96_RS05680 1084217..1084387 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DYY96_RS05685 1084472..1085620 - 1149 WP_001281140.1 alanine racemase -
DYY96_RS05690 1085686..1086045 - 360 WP_000581199.1 holo-ACP synthase -
DYY96_RS05695 1086049..1086540 - 492 WP_001205907.1 PH domain-containing protein -
DYY96_RS05700 1086527..1088110 - 1584 WP_001294637.1 PH domain-containing protein -
DYY96_RS05705 1088103..1088582 - 480 WP_001287077.1 hypothetical protein -
DYY96_RS05710 1088790..1089350 - 561 WP_001092406.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294019 WP_000621175.1 NZ_LT992435:c1084220-1083858 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294019 WP_000948331.1 NZ_LT992435:c1084387-1084217 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References