Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 890020..890796 Replicon chromosome
Accession NZ_LT992435
Organism Staphylococcus aureus isolate 1549-SCV

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag DYY96_RS04440 Protein ID WP_000031109.1
Coordinates 890020..890172 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DYY96_RS04445 Protein ID WP_001251224.1
Coordinates 890197..890796 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYY96_RS04420 885826..886647 + 822 WP_000669377.1 RluA family pseudouridine synthase -
DYY96_RS04425 887104..888489 - 1386 WP_000116239.1 class II fumarate hydratase -
DYY96_RS04430 888685..889080 - 396 WP_000901019.1 hypothetical protein -
DYY96_RS04440 890020..890172 - 153 WP_000031109.1 hypothetical protein Toxin
DYY96_RS04445 890197..890796 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
DYY96_RS04450 890955..891425 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DYY96_RS04455 891430..892557 - 1128 WP_000379990.1 tRNA epoxyqueuosine(34) reductase QueG -
DYY96_RS04460 892708..893430 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
DYY96_RS04465 893423..894880 - 1458 WP_000649916.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5950.31 Da        Isoelectric Point: 3.9075

>T294016 WP_000031109.1 NZ_LT992435:c890172-890020 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT294016 WP_001251224.1 NZ_LT992435:c890796-890197 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References