Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1103595..1104109 Replicon chromosome
Accession NZ_LT992434
Organism Staphylococcus aureus isolate 1549-WT

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag DYY92_RS05765 Protein ID WP_000581795.1
Coordinates 1103595..1103804 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag DYY92_RS05770 Protein ID WP_000138930.1
Coordinates 1103816..1104109 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYY92_RS05745 1099103..1100461 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DYY92_RS05750 1100476..1101546 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
DYY92_RS05755 1101864..1103066 + 1203 WP_001109939.1 rod shape-determining protein RodA -
DYY92_RS05760 1103330..1103467 - 138 WP_000828354.1 hypothetical protein -
DYY92_RS05765 1103595..1103804 - 210 WP_000581795.1 heavy-metal-associated domain-containing protein Toxin
DYY92_RS05770 1103816..1104109 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
DYY92_RS05775 1104275..1105759 + 1485 WP_000571562.1 cardiolipin synthase -
DYY92_RS05780 1105787..1106434 + 648 WP_001187625.1 HD domain-containing protein -
DYY92_RS05790 1106984..1107856 - 873 WP_000725802.1 membrane protein insertase YidC -
DYY92_RS05795 1107942..1108583 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T294012 WP_000581795.1 NZ_LT992434:c1103804-1103595 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT294012 WP_000138930.1 NZ_LT992434:c1104109-1103816 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References