Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1083852..1084381 Replicon chromosome
Accession NZ_LT992434
Organism Staphylococcus aureus isolate 1549-WT

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DYY92_RS05675 Protein ID WP_000621175.1
Coordinates 1083852..1084214 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DYY92_RS05680 Protein ID WP_000948331.1
Coordinates 1084211..1084381 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYY92_RS05650 1080831..1081601 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
DYY92_RS05655 1081576..1082055 - 480 WP_001190825.1 anti-sigma B factor RsbW -
DYY92_RS05660 1082057..1082383 - 327 WP_001052491.1 anti-sigma factor antagonist -
DYY92_RS05665 1082502..1083503 - 1002 WP_042744356.1 PP2C family protein-serine/threonine phosphatase -
DYY92_RS05675 1083852..1084214 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DYY92_RS05680 1084211..1084381 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DYY92_RS05685 1084466..1085614 - 1149 WP_001281140.1 alanine racemase -
DYY92_RS05690 1085680..1086039 - 360 WP_000581199.1 holo-ACP synthase -
DYY92_RS05695 1086043..1086534 - 492 WP_001205907.1 PH domain-containing protein -
DYY92_RS05700 1086521..1088104 - 1584 WP_001294637.1 PH domain-containing protein -
DYY92_RS05705 1088097..1088576 - 480 WP_001287077.1 hypothetical protein -
DYY92_RS05710 1088784..1089344 - 561 WP_001092406.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294011 WP_000621175.1 NZ_LT992434:c1084214-1083852 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294011 WP_000948331.1 NZ_LT992434:c1084381-1084211 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References