Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 552746..554466 Replicon chromosome
Accession NC_021174
Organism Burkholderia thailandensis MSMB121

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BTI_RS20335 Protein ID WP_015603503.1
Coordinates 553117..554466 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BTI_RS20330 Protein ID WP_006028958.1
Coordinates 552746..553120 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTI_RS20320 548172..549584 - 1413 WP_041861944.1 cellulase -
BTI_RS20325 549589..551931 - 2343 WP_041861945.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -
BTI_RS20330 552746..553120 + 375 WP_006028958.1 helix-turn-helix domain-containing protein Antitoxin
BTI_RS20335 553117..554466 + 1350 WP_015603503.1 type II toxin-antitoxin system HipA family toxin Toxin
BTI_RS20340 554494..555030 - 537 WP_015602732.1 hypothetical protein -
BTI_RS20345 555027..556046 - 1020 WP_015603595.1 AAA family ATPase -
BTI_RS20350 556187..556636 - 450 WP_009915517.1 hypothetical protein -
BTI_RS20355 556854..557768 - 915 WP_015603341.1 LysR family transcriptional regulator -
BTI_RS20360 557920..558903 + 984 WP_006028964.1 agmatinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-71)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49633.54 Da        Isoelectric Point: 8.7576

>T29401 WP_015603503.1 NC_021174:553117-554466 [Burkholderia thailandensis MSMB121]
VSARRARTARLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSPFELLATLGRDCVGALQMLPPDEAPDDLERIRGHALADADIARLLRDITSAPQAGEHEPLDDLRLSI
AGAQEKTALLRHRGRWLLPDGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPVAHCDIAHFDGQKALVV
ERFDRRPSSDARWILRLPQEDMCQATGTSALDKYQADGGPGIETIMGVLAGSERAADRYAFFAAQIVFWLLAATDGHAKN
FSIAHLPGNRYRSTPLYDVLSAHPVIGRGADRLPAQRARLAMGVRGKHVHYLIHQIQRRHWIAQGQRVGFAPAEVDDIIG
ALTARTEGVADEVSARLPRDFPMDVADAIFNGMRRLSAKLAAGAAARAS

Download         Length: 1350 bp

>T29401 NC_021174:553117-554466 [Burkholderia thailandensis MSMB121]
GTGAGCGCGCGCCGCGCGCGCACCGCGCGCCTGCACCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCACGCGCG
CGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGCGGACCCGCAAGGCCGCCCGCTGTCGCTGTCGCTGCCGTTCA
CGCCGGGCAACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAGCCGATCCGC
CGGCGGATCGCGATGCGCTACAGGACGGGCGGCACGTCGCCGTTCGAGCTGCTCGCGACGCTCGGCCGCGATTGCGTCGG
CGCGCTGCAGATGCTGCCGCCCGACGAGGCGCCGGACGATCTCGAACGCATCCGCGGCCACGCGCTCGCCGATGCGGACA
TCGCACGCCTGCTGCGCGACATCACGTCCGCGCCGCAAGCCGGCGAGCACGAGCCGCTCGACGACCTGCGCCTGTCGATC
GCCGGCGCGCAGGAAAAGACCGCGCTGCTGCGCCATCGCGGCCGCTGGCTGCTGCCCGACGGCAGCACGCCGACCACGCA
CATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCGGACATGCGCACGTCGGTCGAGAACGAATGGCTGTGCT
CGAAGATCGTCGCCGCATACGGATTGCCGGTCGCGCATTGCGACATCGCGCATTTCGACGGCCAGAAGGCGCTCGTCGTC
GAGCGCTTCGACCGCAGGCCGTCGAGCGACGCGCGCTGGATCCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCAACCGG
CACGTCCGCGCTCGACAAATATCAGGCAGATGGCGGGCCGGGCATCGAGACGATCATGGGCGTGCTCGCCGGCTCCGAGC
GCGCGGCCGACCGCTACGCGTTCTTCGCGGCGCAGATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAGAAC
TTCAGCATCGCGCATCTGCCGGGCAACCGCTATCGATCGACGCCGCTTTACGACGTGCTGTCCGCGCATCCGGTGATCGG
CCGCGGGGCGGACCGGTTGCCGGCGCAGCGCGCGCGGCTCGCGATGGGCGTGCGCGGCAAGCACGTCCATTACCTGATCC
ACCAGATCCAGCGGCGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCGGCCGAAGTCGACGACATCATCGGC
GCGTTGACCGCGCGCACCGAGGGCGTCGCCGACGAAGTATCGGCCAGGCTGCCGCGAGATTTTCCGATGGACGTCGCCGA
TGCGATCTTCAACGGGATGCGTCGCCTGAGCGCGAAACTCGCGGCCGGCGCGGCCGCGCGAGCGTCGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13827.14 Da        Isoelectric Point: 11.8677

>AT29401 WP_006028958.1 NC_021174:552746-553120 [Burkholderia thailandensis MSMB121]
MAIIIEHEIKTLDQLRPILRGFRKVAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRVLDVELTLTHVHTTSA
KQVVKQAAAPARKAANRPMPAPRAAERTPRPARKRAAPKQREDW

Download         Length: 375 bp

>AT29401 NC_021174:552746-553120 [Burkholderia thailandensis MSMB121]
ATGGCCATCATCATCGAACACGAGATCAAGACGCTCGACCAATTGCGGCCCATCCTGCGAGGCTTCCGCAAGGTGGCCGG
ATTGACGCAAGCGATGCTCGCGAGCCGTCTCGGCGTCACGCAGCAGACGTATGCGCAATTCGAGGCGAACCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGTCCTCGACGTCGAGCTCACGCTGACCCACGTCCATACCACTTCCGCG
AAGCAAGTCGTCAAGCAGGCCGCCGCGCCCGCGCGCAAGGCCGCGAACCGGCCGATGCCCGCCCCGCGCGCCGCCGAGCG
CACGCCCCGCCCCGCGCGCAAGCGCGCCGCCCCGAAGCAGCGGGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References