Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 12825..13351 Replicon plasmid pC45-p2
Accession NZ_LT991959
Organism Enterobacter cloacae complex sp. isolate C45

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DBR02_RS25305 Protein ID WP_107535700.1
Coordinates 12825..13112 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag DBR02_RS25310 Protein ID WP_000534858.1
Coordinates 13112..13351 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR02_RS25300 11645..12634 + 990 WP_107535699.1 tyrosine-type recombinase/integrase -
DBR02_RS25305 12825..13112 - 288 WP_107535700.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
DBR02_RS25310 13112..13351 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
DBR02_RS25320 14509..15090 + 582 WP_004118277.1 hypothetical protein -
DBR02_RS25325 15238..16269 + 1032 WP_004118274.1 Abi family protein -
DBR02_RS25330 16822..17730 + 909 WP_107535757.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / aph(6)-Id / aph(3'')-Ib - 1..142732 142732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11241.22 Da        Isoelectric Point: 10.1967

>T294006 WP_107535700.1 NZ_LT991959:c13112-12825 [Enterobacter cloacae complex sp.]
MTYFLDFDERALKEWRKLGSTVREQLKKKLAEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVIVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT294006 WP_000534858.1 NZ_LT991959:c13351-13112 [Enterobacter cloacae complex sp.]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References