Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 241082..241608 Replicon plasmid pC45-VIM4
Accession NZ_LT991958
Organism Enterobacter cloacae complex sp. isolate C45

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag DBR02_RS24900 Protein ID WP_000323025.1
Coordinates 241082..241369 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag DBR02_RS24905 Protein ID WP_000534858.1
Coordinates 241369..241608 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR02_RS26830 236652..236828 - 177 WP_001371930.1 hypothetical protein -
DBR02_RS24870 237339..238283 + 945 WP_000778029.1 DUF5417 domain-containing protein -
DBR02_RS24875 238382..238981 + 600 WP_001031420.1 hypothetical protein -
DBR02_RS24880 239041..239391 + 351 WP_000743059.1 hypothetical protein -
DBR02_RS24885 239438..239641 + 204 WP_001015183.1 hypothetical protein -
DBR02_RS24890 239923..240243 + 321 WP_000332796.1 hypothetical protein -
DBR02_RS24895 240852..241010 - 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
DBR02_RS24900 241082..241369 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
DBR02_RS24905 241369..241608 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
DBR02_RS24915 241871..242794 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
DBR02_RS24920 242994..243566 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
DBR02_RS24925 244042..245280 - 1239 WP_000219087.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaVIM-4 / aac(6')-Il / dfrA1 / aadA1 / qacE / sul1 / blaTEM-1B / ant(2'')-Ia / aadA2 / qnrA1 / tet(A) / mcr-9 - 1..299117 299117


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T294005 WP_000323025.1 NZ_LT991958:c241369-241082 [Enterobacter cloacae complex sp.]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT294005 WP_000534858.1 NZ_LT991958:c241608-241369 [Enterobacter cloacae complex sp.]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References