Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4333455..4334200 Replicon chromosome
Accession NZ_LT991957
Organism Enterobacter cloacae complex sp. isolate C45

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag DBR02_RS21290 Protein ID WP_107535371.1
Coordinates 4333455..4333946 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A4R0FU91
Locus tag DBR02_RS21295 Protein ID WP_063451299.1
Coordinates 4333934..4334200 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR02_RS21265 4328642..4329400 + 759 WP_107535367.1 DeoR/GlpR family DNA-binding transcription regulator -
DBR02_RS21270 4329505..4330797 + 1293 WP_107535368.1 glycoside hydrolase -
DBR02_RS21275 4330883..4331551 + 669 WP_063451313.1 epoxyqueuosine reductase QueH -
DBR02_RS21280 4331823..4332788 + 966 WP_107535369.1 hypothetical protein -
DBR02_RS21285 4332804..4333373 + 570 WP_107535370.1 hypothetical protein -
DBR02_RS21290 4333455..4333946 - 492 WP_107535371.1 GNAT family N-acetyltransferase Toxin
DBR02_RS21295 4333934..4334200 - 267 WP_063451299.1 DUF1778 domain-containing protein Antitoxin
DBR02_RS21300 4334288..4335202 - 915 WP_107535372.1 LysR family transcriptional regulator -
DBR02_RS21305 4335330..4336709 + 1380 WP_107535677.1 DHA2 family efflux MFS transporter permease subunit -
DBR02_RS21310 4336722..4337717 - 996 WP_107535373.1 DUF2891 domain-containing protein -
DBR02_RS21315 4337727..4338713 - 987 WP_063866697.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(34-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17825.62 Da        Isoelectric Point: 10.2227

>T293999 WP_107535371.1 NZ_LT991957:c4333946-4333455 [Enterobacter cloacae complex sp.]
VGRVTAPEPLTSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIVLARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFRASQTQERTLFLRLP
LTR

Download         Length: 492 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT293999 WP_063451299.1 NZ_LT991957:c4334200-4333934 [Enterobacter cloacae complex sp.]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPALEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4R0FU91

References