Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3230307..3230927 Replicon chromosome
Accession NZ_LT991957
Organism Enterobacter cloacae complex sp. isolate C45

Toxin (Protein)


Gene name Hha Uniprot ID V3PUI7
Locus tag DBR02_RS15965 Protein ID WP_010428174.1
Coordinates 3230307..3230525 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag DBR02_RS15970 Protein ID WP_006809850.1
Coordinates 3230553..3230927 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR02_RS15940 3226728..3228296 - 1569 WP_107534814.1 EAL domain-containing protein -
DBR02_RS15945 3228523..3228783 + 261 WP_063451670.1 type B 50S ribosomal protein L31 -
DBR02_RS15950 3228786..3228926 + 141 WP_063451669.1 type B 50S ribosomal protein L36 -
DBR02_RS15955 3228964..3229431 - 468 WP_107534815.1 hypothetical protein -
DBR02_RS15960 3229548..3230099 - 552 WP_107534816.1 maltose O-acetyltransferase -
DBR02_RS15965 3230307..3230525 - 219 WP_010428174.1 hemolysin expression modulator Hha Toxin
DBR02_RS15970 3230553..3230927 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
DBR02_RS15975 3231437..3234583 - 3147 WP_063451666.1 multidrug efflux RND transporter permease subunit AcrB -
DBR02_RS15980 3234606..3235799 - 1194 WP_063451665.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T293998 WP_010428174.1 NZ_LT991957:c3230525-3230307 [Enterobacter cloacae complex sp.]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT293998 WP_006809850.1 NZ_LT991957:c3230927-3230553 [Enterobacter cloacae complex sp.]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V3PUI7

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References