293997

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3113791..3114506 Replicon chromosome
Accession NZ_LT991957
Organism Enterobacter cloacae complex sp. isolate C45

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8I0UM05
Locus tag DBR02_RS15415 Protein ID WP_023303149.1
Coordinates 3114138..3114506 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8I0UJV2
Locus tag DBR02_RS15410 Protein ID WP_023303148.1
Coordinates 3113791..3114117 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR02_RS15380 3108825..3110090 + 1266 WP_023303143.1 hypothetical protein -
DBR02_RS15385 3110399..3110833 + 435 WP_023303144.1 hypothetical protein -
DBR02_RS15390 3110892..3111731 + 840 WP_023303145.1 hypothetical protein -
DBR02_RS15400 3112421..3113242 + 822 WP_023303146.1 DUF945 domain-containing protein -
DBR02_RS15405 3113308..3113778 + 471 WP_023303147.1 DNA repair protein RadC -
DBR02_RS15410 3113791..3114117 + 327 WP_023303148.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DBR02_RS15415 3114138..3114506 + 369 WP_023303149.1 TA system toxin CbtA family protein Toxin
DBR02_RS15420 3114863..3116800 - 1938 WP_107534771.1 bifunctional diguanylate cyclase/phosphodiesterase -
DBR02_RS15425 3116818..3117312 - 495 WP_063869143.1 molybdopterin-dependent oxidoreductase -
DBR02_RS26605 3117674..3117838 + 165 WP_157959557.1 hypothetical protein -
DBR02_RS15430 3117855..3118364 + 510 WP_107534772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3094304..3118364 24060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13727.91 Da        Isoelectric Point: 8.2822

>T293997 WP_023303149.1 NZ_LT991957:3114138-3114506 [Enterobacter cloacae complex sp.]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Download         Length: 369 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12215.04 Da        Isoelectric Point: 7.0266

>AT293997 WP_023303148.1 NZ_LT991957:3113791-3114117 [Enterobacter cloacae complex sp.]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References