Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2172921..2173583 Replicon chromosome
Accession NZ_LT991957
Organism Enterobacter cloacae complex sp. isolate C45

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DBR02_RS10875 Protein ID WP_107534356.1
Coordinates 2173185..2173583 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DBR02_RS10870 Protein ID WP_107534354.1
Coordinates 2172921..2173181 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR02_RS10845 2168136..2169257 - 1122 WP_107534350.1 efflux RND transporter periplasmic adaptor subunit -
DBR02_RS10850 2169405..2169974 - 570 WP_022646570.1 TetR/AcrR family transcriptional regulator -
DBR02_RS10855 2170161..2170580 + 420 WP_063452086.1 GNAT family N-acetyltransferase -
DBR02_RS10860 2170577..2171224 - 648 WP_107534352.1 TetR/AcrR family transcriptional regulator -
DBR02_RS10865 2171304..2172803 + 1500 WP_063868676.1 MFS transporter -
DBR02_RS10870 2172921..2173181 + 261 WP_107534354.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DBR02_RS10875 2173185..2173583 + 399 WP_107534356.1 type II toxin-antitoxin system VapC family toxin Toxin
DBR02_RS10880 2173773..2174573 + 801 WP_107534357.1 lipoprotein NlpA -
DBR02_RS10885 2174592..2175272 - 681 WP_107534359.1 EAL domain-containing protein -
DBR02_RS10890 2175347..2175967 - 621 WP_063868682.1 response regulator transcription factor -
DBR02_RS10895 2176542..2177177 + 636 WP_107534361.1 helix-turn-helix transcriptional regulator -
DBR02_RS10900 2177184..2178248 - 1065 WP_107534363.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14721.93 Da        Isoelectric Point: 5.9786

>T293996 WP_107534356.1 NZ_LT991957:2173185-2173583 [Enterobacter cloacae complex sp.]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITICAWDSEAAATYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFGMVQDLTVEDWTTAA

Download         Length: 399 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10208.48 Da        Isoelectric Point: 6.7299

>AT293996 WP_107534354.1 NZ_LT991957:2172921-2173181 [Enterobacter cloacae complex sp.]
MERTAILFKKGRHQAVVLPEEFAFETESVYIRRDEEGNVVLTARSEKERHRDNFLRMLKQTHVPDSFLSKEERNQSYTTR
DPLEGL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References