Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 2028211..2028827 Replicon chromosome
Accession NZ_LT991957
Organism Enterobacter cloacae complex sp. isolate C45

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DBR02_RS10155 Protein ID WP_077221056.1
Coordinates 2028211..2028582 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4R0FQN1
Locus tag DBR02_RS10160 Protein ID WP_063449683.1
Coordinates 2028585..2028827 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR02_RS10140 2025711..2026613 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
DBR02_RS10145 2026610..2027245 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
DBR02_RS10150 2027242..2028171 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
DBR02_RS10155 2028211..2028582 - 372 WP_077221056.1 type II toxin-antitoxin system VapC family toxin Toxin
DBR02_RS10160 2028585..2028827 - 243 WP_063449683.1 ribbon-helix-helix domain-containing protein Antitoxin
DBR02_RS10165 2029026..2029946 + 921 WP_107534259.1 alpha/beta hydrolase -
DBR02_RS10170 2029955..2030896 - 942 WP_063449681.1 fatty acid biosynthesis protein FabY -
DBR02_RS10175 2030941..2031378 - 438 WP_063449680.1 D-tyrosyl-tRNA(Tyr) deacylase -
DBR02_RS10180 2031375..2032256 - 882 WP_063449679.1 virulence factor BrkB family protein -
DBR02_RS10185 2032250..2032849 - 600 WP_107534261.1 glucose-1-phosphatase -
DBR02_RS10190 2032968..2033768 - 801 WP_107534263.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13567.63 Da        Isoelectric Point: 6.7549

>T293994 WP_077221056.1 NZ_LT991957:c2028582-2028211 [Enterobacter cloacae complex sp.]
MEHMAVFDTNILIDLFNNHVEAADTIDRTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVVLR
EKHGMKLPDAIILATAQSRNCPLVSRNTKDFAGIAGVVSPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9475.63 Da        Isoelectric Point: 4.1849

>AT293994 WP_063449683.1 NZ_LT991957:c2028827-2028585 [Enterobacter cloacae complex sp.]
MSLLADFEMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4R0FQN1

References