Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1905224..1905828 Replicon chromosome
Accession NZ_LT991957
Organism Enterobacter cloacae complex sp. isolate C45

Toxin (Protein)


Gene name hicA Uniprot ID A0A4Q4AAS0
Locus tag DBR02_RS09590 Protein ID WP_057979982.1
Coordinates 1905643..1905828 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4Q4AAR0
Locus tag DBR02_RS09585 Protein ID WP_063865844.1
Coordinates 1905224..1905628 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR02_RS09570 1901137..1903167 + 2031 WP_107534191.1 alpha-amylase -
DBR02_RS09575 1903298..1904551 + 1254 WP_063865841.1 valine--pyruvate transaminase -
DBR02_RS09580 1904559..1905014 - 456 WP_063865843.1 4Fe-4S dicluster domain-containing protein -
DBR02_RS09585 1905224..1905628 - 405 WP_063865844.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DBR02_RS09590 1905643..1905828 - 186 WP_057979982.1 type II toxin-antitoxin system HicA family toxin Toxin
DBR02_RS09595 1906073..1907611 - 1539 WP_063865846.1 aldehyde dehydrogenase AldB -
DBR02_RS09600 1907778..1908662 + 885 WP_107534193.1 ROK family protein -
DBR02_RS09605 1908666..1910504 - 1839 WP_107534195.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6852.08 Da        Isoelectric Point: 11.5191

>T293993 WP_057979982.1 NZ_LT991957:c1905828-1905643 [Enterobacter cloacae complex sp.]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15055.02 Da        Isoelectric Point: 4.3984

>AT293993 WP_063865844.1 NZ_LT991957:c1905628-1905224 [Enterobacter cloacae complex sp.]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPFPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGKVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q4AAS0

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q4AAR0

References