Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1534386..1535079 Replicon chromosome
Accession NC_021173
Organism Burkholderia thailandensis MSMB121

Toxin (Protein)


Gene name tad Uniprot ID A0A132EML3
Locus tag BTI_RS07025 Protein ID WP_015601891.1
Coordinates 1534702..1535079 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag BTI_RS07020 Protein ID WP_015600977.1
Coordinates 1534386..1534721 (-) Length 112 a.a.

Genomic Context

BTI_RS07005BTI_RS07010BTI_RS07015BTI_RS07030BTI_RS07045BTI_RS33165BTI_RS07020BTI_RS07025BTI_RS07035BTI_RS07040
Location: 1530502..1531050 (549 bp)
Type: Others
Protein ID: WP_015600544.1
Location: 1531043..1533406 (2364 bp)
Type: Others
Protein ID: Protein_1405
Location: 1533516..1534196 (681 bp)
Type: Others
Protein ID: WP_015601902.1
Location: 1535491..1536960 (1470 bp)
Type: Others
Protein ID: WP_015601175.1
Location: 1538940..1540070 (1131 bp)
Type: Others
Protein ID: WP_015601089.1
Location: 1534234..1534389 (156 bp)
Type: Others
Protein ID: Protein_1407
Location: 1534386..1534721 (336 bp)
Type: Antitoxin
Protein ID: WP_015600977.1
Location: 1534702..1535079 (378 bp)
Type: Toxin
Protein ID: WP_015601891.1
Location: 1537097..1537618 (522 bp)
Type: Others
Protein ID: WP_015602266.1
Location: 1537865..1538494 (630 bp)
Type: Others
Protein ID: WP_015602117.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BTI_RS070051530502..1531050+549WP_015600544.1hypothetical protein-
BTI_RS070101531043..1533406+2364Protein_1405DEAD/DEAH box helicase family protein-
BTI_RS070151533516..1534196+681WP_015601902.1hypothetical protein-
BTI_RS331651534234..1534389-156Protein_1407HigA family addiction module antidote protein-
BTI_RS070201534386..1534721-336WP_015600977.1helix-turn-helix domain-containing proteinAntitoxin
BTI_RS070251534702..1535079-378WP_015601891.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BTI_RS070301535491..1536960+1470WP_015601175.1aldehyde dehydrogenase family protein-
BTI_RS070351537097..1537618-522WP_015602266.1DUF2867 domain-containing protein-
BTI_RS070401537865..1538494-630WP_015602117.1TetR/AcrR family transcriptional regulator-
BTI_RS070451538940..1540070+1131WP_015601089.1alpha/beta fold hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1528317..154007011753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13718.79 Da        Isoelectric Point: 8.8594

>T29399 WP_015601891.1 NC_021173:c1535079-1534702 [Burkholderia thailandensis MSMB121]
MADKEKPLEWIASSYKDLMALPPDVRRRFGYALSLAQMGDQDDAAKVLKGFGGAGVLEVVEDDTGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKGDMDIIRARLKVAEALAQELRNAKTNH

Download         Length: 378 bp

>T29399 NC_021173:c1535079-1534702 [Burkholderia thailandensis MSMB121]
ATGGCCGACAAAGAAAAACCTCTCGAATGGATTGCGAGCAGCTACAAGGATCTGATGGCGTTGCCGCCCGATGTTCGCCG
GCGCTTCGGTTACGCGCTGTCGTTAGCGCAGATGGGCGACCAGGACGATGCGGCAAAGGTGCTCAAGGGCTTCGGCGGAG
CCGGCGTGCTAGAGGTCGTCGAGGATGATACCGGCGGCACGTACCGGGCCGTCTATACAGTCAAGTTCGCCGAGGCGGTG
TTCGTCCTGCACTGCTTCCAGAAAAAGAGCAAGAGTGGGATCGCCACGCCGAAAGGCGACATGGACATCATTCGCGCTCG
GTTGAAAGTGGCCGAAGCATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12152.36 Da        Isoelectric Point: 10.2130

>AT29399 WP_015600977.1 NC_021173:c1534721-1534386 [Burkholderia thailandensis MSMB121]
MQKRIIEGVEVQRGSGNVYADLGLPDAEKLKIKTGLVIEIRKAMRALGLTQQAAAKRMGIPQPKVSGMMHGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLAVA

Download         Length: 336 bp

>AT29399 NC_021173:c1534721-1534386 [Burkholderia thailandensis MSMB121]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCGGTTCGGGCAATGTCTATGCCGACCTCGGCTTGCCCGATGC
AGAAAAACTGAAGATCAAGACCGGCTTGGTAATCGAAATCAGAAAAGCCATGCGTGCCCTCGGACTCACTCAACAAGCCG
CGGCGAAACGCATGGGCATTCCGCAGCCGAAGGTGTCCGGCATGATGCATGGTGACTTCACTAACCTGTCCGAGCGCAAG
CTGATGGACTGCTTGAATCGGCTAGGCTACGACATCGAGATCAAGGTACGGCCGGCCGCCGAACCGATCGGGCATCTCAC
GCTCGCGGTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A132EML3

Antitoxin

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Source
ID
Structure
No matching records found

References