Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 105697..106223 Replicon plasmid pC309-p2
Accession NZ_LT991956
Organism Enterobacter hormaechei subsp. steigerwaltii isolate C309

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag DBR08_RS25190 Protein ID WP_000323025.1
Coordinates 105936..106223 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag DBR08_RS25185 Protein ID WP_004196370.1
Coordinates 105697..105936 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR08_RS25155 101034..101226 - 193 Protein_116 MFS transporter -
DBR08_RS25160 101256..102233 + 978 WP_004196334.1 chromate resistance protein -
DBR08_RS25165 102190..103566 + 1377 WP_004196363.1 chromate efflux transporter -
DBR08_RS25170 103597..104286 - 690 WP_004196322.1 hypothetical protein -
DBR08_RS25175 104300..105037 - 738 WP_008460272.1 HupE/UreJ family protein -
DBR08_RS25180 105081..105446 - 366 WP_009651956.1 hypothetical protein -
DBR08_RS25185 105697..105936 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
DBR08_RS25190 105936..106223 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
DBR08_RS25195 106290..107324 - 1035 Protein_124 IS481 family transposase -
DBR08_RS25200 107396..107554 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
DBR08_RS25205 108430..108744 + 315 WP_044157807.1 hypothetical protein -
DBR08_RS25210 108805..109266 + 462 WP_013087181.1 hypothetical protein -
DBR08_RS25215 109354..109554 + 201 WP_013087182.1 hypothetical protein -
DBR08_RS25220 109595..110386 + 792 WP_013087183.1 N-6 DNA methylase -
DBR08_RS25225 110428..110763 + 336 WP_013087184.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..183339 183339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T293989 WP_000323025.1 NZ_LT991956:105936-106223 [Enterobacter hormaechei subsp. steigerwaltii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT293989 WP_004196370.1 NZ_LT991956:105697-105936 [Enterobacter hormaechei subsp. steigerwaltii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References