Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 92356..93095 Replicon plasmid pC309-p2
Accession NZ_LT991956
Organism Enterobacter hormaechei subsp. steigerwaltii isolate C309

Toxin (Protein)


Gene name tacT Uniprot ID A0A5E1AVR5
Locus tag DBR08_RS25105 Protein ID WP_013087172.1
Coordinates 92610..93095 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A5E1AWX8
Locus tag DBR08_RS25100 Protein ID WP_012540086.1
Coordinates 92356..92622 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR08_RS25070 87587..88123 - 537 WP_013087166.1 GNAT family N-acetyltransferase -
DBR08_RS25075 88248..89999 - 1752 WP_162875198.1 arsenical pump-driving ATPase -
DBR08_RS25080 90026..90388 - 363 WP_013087168.1 arsenic metallochaperone ArsD family protein -
DBR08_RS25085 90464..91009 - 546 WP_013087169.1 sigma-70 family RNA polymerase sigma factor -
DBR08_RS25090 91018..91731 - 714 WP_013087170.1 arsenical resistance protein ArsH -
DBR08_RS25095 91733..92056 - 324 WP_013087171.1 metalloregulator ArsR/SmtB family transcription factor -
DBR08_RS25100 92356..92622 + 267 WP_012540086.1 DUF1778 domain-containing protein Antitoxin
DBR08_RS25105 92610..93095 + 486 WP_013087172.1 GNAT family N-acetyltransferase Toxin
DBR08_RS25110 93513..94853 + 1341 WP_004196353.1 ISNCY family transposase -
DBR08_RS25120 95109..95531 - 423 WP_032072095.1 nickel resistance OB fold protein NcrY -
DBR08_RS25125 95693..96823 - 1131 WP_004196366.1 Ni(II)/Co(II) efflux transporter permease subunit NcrC -
DBR08_RS25130 96836..97105 - 270 WP_004196355.1 nickel-sensing transcriptional repressor NcrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..183339 183339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17810.62 Da        Isoelectric Point: 9.8560

>T293988 WP_013087172.1 NZ_LT991956:92610-93095 [Enterobacter hormaechei subsp. steigerwaltii]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10076.47 Da        Isoelectric Point: 4.3721

>AT293988 WP_012540086.1 NZ_LT991956:92356-92622 [Enterobacter hormaechei subsp. steigerwaltii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AVR5

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AWX8

References