Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 196242..196768 Replicon plasmid pC309-VIM4
Accession NZ_LT991955
Organism Enterobacter hormaechei subsp. steigerwaltii isolate C309

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag DBR08_RS24175 Protein ID WP_000323025.1
Coordinates 196242..196529 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag DBR08_RS24180 Protein ID WP_000534858.1
Coordinates 196529..196768 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR08_RS25795 191812..191988 - 177 WP_001371930.1 hypothetical protein -
DBR08_RS24145 192499..193443 + 945 WP_000778029.1 DUF5417 domain-containing protein -
DBR08_RS24150 193542..194141 + 600 WP_001031420.1 hypothetical protein -
DBR08_RS24155 194201..194551 + 351 WP_000743059.1 hypothetical protein -
DBR08_RS24160 194598..194801 + 204 WP_001015183.1 hypothetical protein -
DBR08_RS24165 195083..195403 + 321 WP_000332796.1 hypothetical protein -
DBR08_RS24170 196012..196170 - 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
DBR08_RS24175 196242..196529 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
DBR08_RS24180 196529..196768 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
DBR08_RS24190 197031..197954 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
DBR08_RS24195 198154..198726 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
DBR08_RS24200 199202..200440 - 1239 WP_000219087.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaVIM-4 / aac(6')-Il / dfrA1 / aadA1 / qacE / sul1 - 1..254277 254277


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T293984 WP_000323025.1 NZ_LT991955:c196529-196242 [Enterobacter hormaechei subsp. steigerwaltii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT293984 WP_000534858.1 NZ_LT991955:c196768-196529 [Enterobacter hormaechei subsp. steigerwaltii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References