Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) rlegTA/AbiEii(toxin)
Location 3571838..3573365 Replicon chromosome
Accession NC_021172
Organism Hyphomicrobium denitrificans 1NES1

Toxin (Protein)


Gene name rlegT Uniprot ID N0BC13
Locus tag HYPDE_RS17215 Protein ID WP_015599821.1
Coordinates 3572448..3573365 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID N0BH83
Locus tag HYPDE_RS17210 Protein ID WP_015599820.1
Coordinates 3571838..3572458 (+) Length 207 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYPDE_RS17185 3567089..3567283 - 195 WP_015599814.1 hypothetical protein -
HYPDE_RS17190 3567286..3567660 - 375 WP_015599815.1 hypothetical protein -
HYPDE_RS17195 3567671..3568150 - 480 WP_015599816.1 hypothetical protein -
HYPDE_RS17200 3568247..3570382 - 2136 WP_015599817.1 ParB/RepB/Spo0J family partition protein -
HYPDE_RS17205 3570572..3571531 - 960 WP_015599818.1 DUF1738 domain-containing protein -
HYPDE_RS17210 3571838..3572458 + 621 WP_015599820.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
HYPDE_RS17215 3572448..3573365 + 918 WP_015599821.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HYPDE_RS17220 3573456..3573710 + 255 WP_187290846.1 hypothetical protein -
HYPDE_RS17225 3573707..3575659 + 1953 WP_015599823.1 NTPase KAP -
HYPDE_RS17230 3575659..3576546 + 888 WP_015599824.1 hypothetical protein -
HYPDE_RS17235 3576543..3577892 + 1350 WP_015599825.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 33543.48 Da        Isoelectric Point: 5.4721

>T29398 WP_015599821.1 NC_021172:3572448-3573365 [Hyphomicrobium denitrificans 1NES1]
MPREPRNIGASVRARLLDRARAERSDFQILLTRYALERLLYRLSISPHRDRFILKGAMLFVTWVADPFRPTRDLDLLGSG
DNGAEAIAETFRVICAQPVADDGVIFNVAALQAAPIREEVEYGGVRVRTTATIAGARIPIQVDVGFGDTVTPAPVEIDYP
TLLDAPAPHLRAYPIETVVAEKFEALVALGMANSRLKDFYDLWLIAHTFKFGRPALSKAVQRTFERRGTALPADIPVGLT
DEFAAAWAVQWRTLLTRERMAAAPEGFTTVIADLQDFLMPLLGGSNTESVWPAGGPWSLGASKDE

Download         Length: 918 bp

>T29398 NC_021172:3572448-3573365 [Hyphomicrobium denitrificans 1NES1]
ATGCCACGTGAGCCTCGCAATATTGGCGCGTCGGTGCGGGCCCGCCTGCTGGATCGGGCGCGCGCGGAGCGATCCGATTT
CCAGATTCTGCTGACGCGCTATGCGCTCGAGCGTCTGCTCTACCGGCTGAGCATTTCCCCCCATCGCGACCGCTTCATTC
TAAAGGGGGCGATGCTCTTTGTGACCTGGGTCGCCGATCCCTTCCGGCCGACTCGCGATCTCGACCTGCTCGGTTCTGGC
GACAATGGCGCCGAGGCGATCGCGGAAACCTTCCGCGTCATCTGCGCCCAGCCGGTCGCCGATGACGGTGTGATATTCAA
TGTCGCTGCGCTGCAGGCGGCGCCGATCCGCGAGGAAGTGGAATATGGCGGCGTACGGGTACGCACAACCGCGACGATCG
CCGGTGCGCGCATCCCAATTCAAGTTGATGTCGGCTTCGGCGATACCGTCACGCCGGCGCCGGTCGAGATCGACTATCCC
ACCTTGCTGGACGCCCCGGCACCGCATCTTCGAGCCTACCCGATCGAGACGGTGGTGGCGGAGAAATTTGAAGCCTTGGT
CGCGCTCGGCATGGCCAACAGCCGACTCAAGGATTTCTATGATCTTTGGCTGATTGCGCACACCTTCAAATTTGGGCGGC
CCGCACTTTCTAAAGCCGTGCAGCGCACATTCGAGCGGCGCGGCACAGCGCTCCCAGCCGATATTCCGGTTGGTTTGACG
GATGAATTCGCGGCGGCGTGGGCTGTCCAGTGGCGAACCTTGCTCACGCGCGAGCGCATGGCGGCGGCGCCAGAAGGATT
CACGACAGTCATCGCTGATCTTCAGGATTTCTTGATGCCGTTACTTGGTGGGTCAAACACAGAGTCGGTTTGGCCGGCCG
GCGGGCCATGGTCGCTCGGAGCATCGAAAGATGAATAG

Antitoxin


Download         Length: 207 a.a.        Molecular weight: 23351.16 Da        Isoelectric Point: 9.9356

>AT29398 WP_015599820.1 NC_021172:3571838-3572458 [Hyphomicrobium denitrificans 1NES1]
MTSANAQRVRALDLLKSRGMLRQKDFMAEGIGPETLARLVREAAVVRPARGLYQLPDTQIEAAHMLAEAAVLVPKGVVCL
TSALQYHELTLQMPSAVWMAIERTAWRPKIDYPRIRFVRFTGSALTEGVERHRVENIEVPITDPARTIVDCFRYRAKVGL
DVAMEGLREGLRRQRCTPDDLWRYARTARVWSVMRPYVEAMAADAT

Download         Length: 621 bp

>AT29398 NC_021172:3571838-3572458 [Hyphomicrobium denitrificans 1NES1]
ATGACATCGGCGAACGCCCAGCGAGTTCGTGCCCTAGATCTCTTGAAGTCGCGGGGAATGCTCCGCCAGAAGGACTTCAT
GGCCGAAGGCATTGGCCCGGAGACGCTCGCCCGTCTCGTACGGGAGGCGGCGGTCGTGCGTCCGGCCCGGGGCCTCTATC
AGCTCCCGGACACCCAGATCGAGGCGGCCCACATGCTTGCCGAAGCCGCCGTGCTGGTTCCCAAAGGGGTCGTCTGCCTG
ACCTCGGCGCTTCAATATCATGAACTGACGCTGCAGATGCCGTCAGCCGTATGGATGGCGATCGAGCGTACCGCCTGGCG
GCCGAAGATCGACTATCCGCGCATCCGCTTCGTGCGCTTCACCGGATCGGCGCTGACCGAGGGGGTTGAGCGTCATCGCG
TCGAGAACATCGAGGTCCCCATCACGGATCCGGCGCGGACCATCGTCGACTGTTTCCGCTACCGGGCCAAGGTCGGCCTC
GATGTCGCCATGGAAGGACTTCGCGAAGGCCTCCGCCGCCAGCGATGTACACCTGATGATCTGTGGCGTTACGCGCGAAC
GGCGCGGGTCTGGTCAGTGATGCGCCCTTACGTCGAAGCGATGGCGGCCGATGCCACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB N0BC13


Antitoxin

Source ID Structure
AlphaFold DB N0BH83

References