Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3088620..3089359 Replicon chromosome
Accession NZ_LT991954
Organism Enterobacter hormaechei subsp. steigerwaltii isolate C309

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag DBR08_RS15035 Protein ID WP_003857133.1
Coordinates 3088620..3089105 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag DBR08_RS15040 Protein ID WP_003857131.1
Coordinates 3089093..3089359 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR08_RS15000 3084118..3084732 + 615 WP_080337195.1 NUDIX hydrolase -
DBR08_RS15005 3084916..3085551 - 636 WP_015570517.1 DUF421 domain-containing protein -
DBR08_RS15010 3085561..3086007 - 447 WP_014069654.1 DUF3290 domain-containing protein -
DBR08_RS15020 3086436..3086764 - 329 Protein_2834 helix-turn-helix domain-containing protein -
DBR08_RS15025 3087019..3087984 + 966 WP_045338503.1 hypothetical protein -
DBR08_RS15030 3088000..3088569 + 570 WP_017382346.1 hypothetical protein -
DBR08_RS15035 3088620..3089105 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
DBR08_RS15040 3089093..3089359 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
DBR08_RS15045 3089423..3090352 - 930 WP_026080525.1 LysR family transcriptional regulator -
DBR08_RS15050 3090482..3091870 + 1389 WP_017382343.1 MFS transporter -
DBR08_RS15055 3091893..3092888 - 996 WP_017382342.1 DUF2891 domain-containing protein -
DBR08_RS15060 3092898..3093884 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T293975 WP_003857133.1 NZ_LT991954:c3089105-3088620 [Enterobacter hormaechei subsp. steigerwaltii]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT293975 WP_003857131.1 NZ_LT991954:c3089359-3089093 [Enterobacter hormaechei subsp. steigerwaltii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References